干旱区生态环境知识资源中心(Arid): Short- and medium-term survival of critically ill patients with solid cancer admitted to the intensive care unit

Arid

DOI	10.21037/apm-21-2352
	Short- and medium-term survival of critically ill patients with solid cancer admitted to the intensive care unit
	Yuan, Zhen-Nan; Wang, Hai-Jun; Gao, Yong; Qu, Shi-Ning; Huang, Chu-Lin; Wang, Hao; Zhang, Hao; Xing, Xue-Zhong
通讯作者	Xing, XZ (corresponding author)，Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Intens Care Unit,Natl Canc Ctr, Beijing 100021, Peoples R China.
来源期刊	ANNALS OF PALLIATIVE MEDICINE
ISSN	2224-5820
EISSN	2224-5839
出版年	2021-12
英文摘要	Background: A great increase in the number of patients needs critical care to the intensive care unit (ICU) due to improvements in oncology. The aim of the study was to explore risk factors affecting survival of critically ill patients with solid cancers in ICU. Methods: The study retrospectively reviewed patients between 2001 and 2012, which were collected by Medical Information Mart for Intensive Care III (MIMIC-III) from the Beth Israel Deaconess Medical Center in Boston, MA, USA. Results: A total of 38,508 adult patients, who were admitted to ICUs and 8,308 (21.6%) were diagnosed as an underlying malignancy; 1,671 and 3,165 adult patients with sold cancer were admitted to surgical ICU (SICU) and medical ICU (MICU), respectively. Patients in SICU had a higher survival rate at the point of 28-, 90-day, and 1-, 3-year than patients in MICU (P<0.001 for all). Multivariate analysis demonstrated that age >= 70 emergency admission, the presence of metastases, Oxford Acute Severity of Illness Score (OASIS) >= 30 and sepsis were independent risk factors affecting 28-day survival in SICU. In MICU, emergency admission, metastatic disease, Sequential Organ Failure Assessment (SOFA) >= 3, Simplified Acute Physiology Score II (SAPS II) >= 39, Acute Physiology Score III (APS III) >= 40, Oxford Acute Severity of Illness Score (OASIS) >= 30, Elixhauser comorbidity index >= 9 and sepsis were independent risk factors for 28-day survival rate. The area under curve (AUC) of the OASIS for predicting ICU mortality was 0.824 [95% confidence interval (CI): 0.805-0.842], which was obviously higher than other scores in SICU. The AUC of the SAPS II for predicting ICU mortality was 0.820 (95% CI: 0.806-0.833), which was slightly higher than other scores in MICU. Conclusions: Patients with cancer in SICU have longer survive time than patients with cancer in MICU. The prediction of prognosis of critically ill cancer patients can guide treatment and optimize medical resources.
英文关键词	Solid cancer intensive care unit (ICU) critical illness prognosis
类型	Article ; Early Access
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000737002800001
WOS关键词	ACUTE PHYSIOLOGY ; MORTALITY ; ADMISSION ; SCORE ; EPIDEMIOLOGY ; MULTICENTER ; SEVERITY ; OUTCOMES ; ILLNESS ; RISK
WOS类目	Health Care Sciences & Services
WOS研究方向	Health Care Sciences & Services
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/377054
作者单位	[Yuan, Zhen-Nan; Wang, Hai-Jun; Gao, Yong; Qu, Shi-Ning; Huang, Chu-Lin; Wang, Hao; Zhang, Hao; Xing, Xue-Zhong] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Intens Care Unit,Natl Canc Ctr, Beijing 100021, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Zhen-Nan,Wang, Hai-Jun,Gao, Yong,et al. Short- and medium-term survival of critically ill patients with solid cancer admitted to the intensive care unit[J],2021.
APA	Yuan, Zhen-Nan.,Wang, Hai-Jun.,Gao, Yong.,Qu, Shi-Ning.,Huang, Chu-Lin.,...&Xing, Xue-Zhong.(2021).Short- and medium-term survival of critically ill patients with solid cancer admitted to the intensive care unit.ANNALS OF PALLIATIVE MEDICINE.
MLA	Yuan, Zhen-Nan,et al."Short- and medium-term survival of critically ill patients with solid cancer admitted to the intensive care unit".ANNALS OF PALLIATIVE MEDICINE (2021).