干旱区生态环境知识资源中心(Arid): Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193

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DOI	10.1021/acs.jnatprod.1c00735
	Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193
	Xing, Li; Chang, Yimin; Zhang, Xiaoqian; Hou, Xuewen; Han, Yaxin; Shah, Mudassir; Zhu, Tianjiao; Peng, Jixing; Zhang, Guojian; Che, Qian; Li, Dehai
通讯作者	Che, Q ; Li, DH (corresponding author)，Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China. ; Li, DH (corresponding author)，Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China.
来源期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
EISSN	1520-6025
出版年	2021-12
英文摘要	Bitetracenomycin A (1) and its diastereomers [(+/-)-bitetracenomycin B, (+/-)-2] were discovered from the cultures of Streptomyces sp. HDN154193. Compounds 1 and (+/-)-2 were the first tetracenomycin dimers obtained from a natural source with sp(3) methine protons at the bridge positions (C-12/12'), which also exhibited broad-spectrum antibacterial activity. The racemate (+/-)-2 was semisynthesized and separated into enantiomers (+)-2 and (-)-2, and the absolute configurations were determined by specific rotation and ECD data. These metabolites exhibited potent antibacterial activity especially against drug-resistant strains (MRSA and MRCNS) with MIC values ranging from 1.0 to 1.9 mu g/mL.
类型	Article ; Early Access
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000735940600001
WOS关键词	A-D
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/377049
作者单位	[Xing, Li; Chang, Yimin; Zhang, Xiaoqian; Hou, Xuewen; Han, Yaxin; Zhu, Tianjiao; Zhang, Guojian; Che, Qian; Li, Dehai] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China; [Shah, Mudassir] Key Lab Testing & Evaluat Aquat Prod Safety & Qua, Minist Agr & Rural Affairs, Beijing 100125, Peoples R China; [Shah, Mudassir] Abbottabad Univ Sci & Technol, Dept Pharm, District Abbottabad 22010, Kpk, Pakistan; [Peng, Jixing] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China; [Zhang, Guojian; Li, Dehai] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Xing, Li,Chang, Yimin,Zhang, Xiaoqian,et al. Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193[J],2021.
APA	Xing, Li.,Chang, Yimin.,Zhang, Xiaoqian.,Hou, Xuewen.,Han, Yaxin.,...&Li, Dehai.(2021).Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193.JOURNAL OF NATURAL PRODUCTS.
MLA	Xing, Li,et al."Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193".JOURNAL OF NATURAL PRODUCTS (2021).