干旱区生态环境知识资源中心(Arid): Genome sequencing and transcriptomic analysis of the Andean killifish Orestias ascotanensis reveals adaptation to high-altitude aquatic life

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DOI	10.1016/j.ygeno.2021.12.018
	Genome sequencing and transcriptomic analysis of the Andean killifish Orestias ascotanensis reveals adaptation to high-altitude aquatic life
	Di Genova, Alex; Nardocci, Gino; Maldonado-Agurto, Rodrigo; Hodar, Christian; Valdivieso, Camilo; Morales, Pamela; Gajardo, Felipe; Marina, Raquel; Gutierrez, Rodrigo A.; Orellana, Ariel; Cambiazo, Veronica; Gonzalez, Mauricio; Glavic, Alvaro; Mendez, Marco A.; Maass, Alejandro; Allende, Miguel L.; Montecino, Martin A.
通讯作者	Montecino, MA (corresponding author)，Univ Andres Bello, Fac Med, Inst Ciencias Biomed, Echaurren 183, Santiago, Chile. ; Allende, ML (corresponding author)，Univ Chile, Fac Ciencias, Dept Biol, Las Palmeras 3425, Santiago, Chile.
来源期刊	GENOMICS
ISSN	0888-7543
EISSN	1089-8646
出版年	2022
卷号	114 期号:1
英文摘要	Orestias ascotanensis (Cyprinodontidae) is a teleost pupfish endemic to springs feeding into the Ascotan saltpan in the Chilean Altiplano (3,700 m.a.s.l.) and represents an opportunity to study adaptations to high-altitude aquatic environments. We have de novo assembled the genome of O. ascotanensis at high coverage. Comparative analysis of the O. ascotanensis genome showed an overall process of contraction, including loss of genes related to Gprotein signaling, chemotaxis and signal transduction, while there was expansion of gene families associated with microtubule-based movement and protein ubiquitination. We identified 818 genes under positive selection, many of which are involved in DNA repair. Additionally, we identified novel and conserved microRNAs expressed in O. ascotanensis and its closely-related species, Orestias gloriae. Our analysis suggests that positive selection and expansion of genes that preserve genome stability are a potential adaptive mechanism to cope with the increased solar UV radiation to which high-altitude animals are exposed to.
英文关键词	Orestias ascotanensis DNA repair High-altitude Desert pupfish Altiplano microRNAs
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000742146100002
WOS关键词	FANCONI-ANEMIA PATHWAY ; GENE DUPLICATION ; DNA-REPAIR ; PROTEIN ; EVOLUTION ; RNA ; UV ; CYPRINODONTIDAE ; TELEOSTEI ; MECHANISM
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376867
作者单位	[Di Genova, Alex; Nardocci, Gino; Maldonado-Agurto, Rodrigo; Hodar, Christian; Valdivieso, Camilo; Morales, Pamela; Gajardo, Felipe; Marina, Raquel; Gutierrez, Rodrigo A.; Orellana, Ariel; Cambiazo, Veronica; Gonzalez, Mauricio; Glavic, Alvaro; Mendez, Marco A.; Maass, Alejandro; Allende, Miguel L.; Montecino, Martin A.] FONDAP Ctr Genome Regulat, Santiago, Chile; [Di Genova, Alex; Maass, Alejandro] Univ Chile, Fac Phys & Math Sci, Dept Math Engn, Ctr Math Modeling, Santiago 2807, Chile; [Di Genova, Alex; Maass, Alejandro] IRL CNRS, Santiago 2807, Chile; [Nardocci, Gino; Maldonado-Agurto, Rodrigo; Marina, Raquel; Montecino, Martin A.] Univ Andres Bello, Fac Med, Inst Biomed Sci, Santiago, Chile; [Nardocci, Gino; Maldonado-Agurto, Rodrigo; Marina, Raquel; Montecino, Martin A.] Univ Andres Bello, Fac Life Sci, Santiago, Chile; [Hodar, Christian; Cambiazo, Veronica; Gonzalez, Mauricio] Univ Chile, Inst Nutr & Food Technol, Santiago, Chile; [Valdivieso, Camilo; Morales, Pamela; Gajardo, Felipe; Glavic, Alvaro...
推荐引用方式 GB/T 7714	Di Genova, Alex,Nardocci, Gino,Maldonado-Agurto, Rodrigo,et al. Genome sequencing and transcriptomic analysis of the Andean killifish Orestias ascotanensis reveals adaptation to high-altitude aquatic life[J],2022,114(1).
APA	Di Genova, Alex.,Nardocci, Gino.,Maldonado-Agurto, Rodrigo.,Hodar, Christian.,Valdivieso, Camilo.,...&Montecino, Martin A..(2022).Genome sequencing and transcriptomic analysis of the Andean killifish Orestias ascotanensis reveals adaptation to high-altitude aquatic life.GENOMICS,114(1).
MLA	Di Genova, Alex,et al."Genome sequencing and transcriptomic analysis of the Andean killifish Orestias ascotanensis reveals adaptation to high-altitude aquatic life".GENOMICS 114.1(2022).