干旱区生态环境知识资源中心(Arid): Antidiarrheal and Cardio-Depressant Effects of Himalaiella heteromalla (D.Don) Raab-Straube: In Vitro, In Vivo, and In Silico Studies

Arid

DOI	10.3390/plants11010078
	Antidiarrheal and Cardio-Depressant Effects of Himalaiella heteromalla (D.Don) Raab-Straube: In Vitro, In Vivo, and In Silico Studies
	Saqib, Fatima; Usman, Faisal; Malik, Shehneela; Bano, Naheed; Ur-Rahman, Najm; Riaz, Muhammad; Marc (Vlaic), Romina Alina; Muresan, Crina Carmen
通讯作者	Saqib, F (corresponding author)，Bahauddin Zakariya Univ, Fac Pharm, Multan 60000, Pakistan. ; Marc, RA (corresponding author)，Univ Agr Sci & Vet Med, Fac Food Sci & Technol, Food Engn Dept, Cluj Napoca 400372, Romania.
来源期刊	PLANTS-BASEL
EISSN	2223-7747
出版年	2022
卷号	11 期号:1
英文摘要	Himalaiella heteromalla (D.Don) Raab-Straube is a commonly used remedy against various diseases. Crude extract and fractions of H. heteromalla were investigated for a gastrointestinal, bronchodilator, cardiovascular, and anti-inflammatory activities. H. heteromalla crude extract (Hh.Cr) relaxed spontaneous contractions and K+ (80 mM)-induced contraction in jejunum tissue dose-dependently. The relaxation of K+ (80 mM) indicates the presence of Ca++ channel blocking (CCB) effect, which was further confirmed by constructing calcium response curves (CRCs) as they caused rightward parallel shift of CRCs in a manner comparable to verapamil, so the spasmolytic effect of Hh.Cr was due to its CCB activity. Application of Hh.Cr on CCh (1 mu M) and K+ (80 mM)-induced contraction in tracheal preparation resulted in complete relaxation, showing its bronchodilator effect mediated through Ca++ channels and cholinergic antagonist activity. Application of Hh.Cr on aortic preparations exhibited vasorelaxant activity through angiotensin and alpha-adrenergic receptors blockage. It also showed the cardio suppressant effect with negative chronotropic and inotropic response in paired atrium preparation. Similar effects were observed in in vivo models, i.e., decreased propulsive movement, wet feces, and inhibition of edema formation.
英文关键词	antidiarrheal calcium ion channel cardio-depressant Himalaiella heteromalla
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000741374600001
WOS关键词	ANTIINFLAMMATORY ACTIVITY ; METHANOLIC EXTRACT ; MEDICINAL-PLANTS ; COLD DESERT ; BRONCHODILATOR ; CALCIUM ; ARCTIGENIN ; CONSTITUENTS ; VASODILATOR ; DIVERSITY
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376816
作者单位	[Saqib, Fatima; Usman, Faisal; Malik, Shehneela] Bahauddin Zakariya Univ, Fac Pharm, Multan 60000, Pakistan; [Bano, Naheed] MNS Univ Agr, Fac Vet & Anim Sci, Multan 60000, Pakistan; [Ur-Rahman, Najm; Riaz, Muhammad] Shaheed Benazir Bhutto Univ, Dept Pharm, Sheringal 18050, Pakistan; [Marc (Vlaic), Romina Alina; Muresan, Crina Carmen] Univ Agr Sci & Vet Med, Fac Food Sci & Technol, Food Engn Dept, Cluj Napoca 400372, Romania
推荐引用方式 GB/T 7714	Saqib, Fatima,Usman, Faisal,Malik, Shehneela,et al. Antidiarrheal and Cardio-Depressant Effects of Himalaiella heteromalla (D.Don) Raab-Straube: In Vitro, In Vivo, and In Silico Studies[J],2022,11(1).
APA	Saqib, Fatima.,Usman, Faisal.,Malik, Shehneela.,Bano, Naheed.,Ur-Rahman, Najm.,...&Muresan, Crina Carmen.(2022).Antidiarrheal and Cardio-Depressant Effects of Himalaiella heteromalla (D.Don) Raab-Straube: In Vitro, In Vivo, and In Silico Studies.PLANTS-BASEL,11(1).
MLA	Saqib, Fatima,et al."Antidiarrheal and Cardio-Depressant Effects of Himalaiella heteromalla (D.Don) Raab-Straube: In Vitro, In Vivo, and In Silico Studies".PLANTS-BASEL 11.1(2022).