干旱区生态环境知识资源中心(Arid): p Pyroptosis-Mediated Molecular Subtypes are Characterized by Distinct Tumor Microenvironment Infiltration Characteristics in Breast Cancer

Arid

DOI	10.2147/JIR.S349186
	p Pyroptosis-Mediated Molecular Subtypes are Characterized by Distinct Tumor Microenvironment Infiltration Characteristics in Breast Cancer
	Xu, Lijun; Hu, Yaomin; Liu, Wenwen
通讯作者	Liu, WW (corresponding author)，Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Geratol, Shanghai 200127, Peoples R China.
来源期刊	JOURNAL OF INFLAMMATION RESEARCH
EISSN	1178-7031
出版年	2022
卷号	15
英文摘要	Background: Numerous reports have highlighted that pyroptosis is closely linked to tumorigenesis and drug resistance of tumors. However, the potential role of pyroptosis in regulating immune cell infiltration in tumor microenvironment (TME) remains unclear. Methods: Here, we performed consensus clustering analysis based on the expression of 10 typical pyroptosis-related regulators (PRRs) to construct pyroptosis-mediated tumor pattern clusters and pyroptosis-related gene signature in breast cancer (BC). GSVA combined with ssGSEA methods were applied to evaluate the differences in biological pathway and immune cell infiltration level, respectively. The PCA method was employed to construct the pyroscore to quantify the pyroptosis pattern level of individual BC patient. Results: We determined three distinct pyro-clusters among 1852 BC samples, which exhibited different survival outcomes and enriched biological processes. The TME features demonstrated that these three clusters corresponded to three established immune profiles: immune-desert, immune-excluded and immune-inflamed phenotype, respectively. Based on pyroptosis-related signature genes, we constructed the pyro-score and stratified BC patients into high and low pyro-score group. Patients with high pyro-score exhibited favorable outcome and increased infiltration of immune cells. Further investigation revealed that high pyro-score was also related to high expression of immunosuppressive molecules, decreased tumor mutation burden (TMB) and high rate of mutation in significantly mutated genes (SMGs) (eg, PIK3CA and CDH1). Conclusion: This research emphasizes the indispensable role of pyroptosis in TME complexity and diversity. Assessing the pyroptosis pattern level of individual BC patient will assist us in better understanding TME features and directing more effective immunotherapeutic approaches.
英文关键词	breast cancer immune landscape immunotherapy pyroptosis tumor microenvironment
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000745541300002
WOS关键词	IMMUNE ; IMMUNOPHENOTYPE ; BLOCKADE ; PACKAGE ; GRADE
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376795
作者单位	[Xu, Lijun; Hu, Yaomin; Liu, Wenwen] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Geratol, Shanghai 200127, Peoples R China
推荐引用方式 GB/T 7714	Xu, Lijun,Hu, Yaomin,Liu, Wenwen. p Pyroptosis-Mediated Molecular Subtypes are Characterized by Distinct Tumor Microenvironment Infiltration Characteristics in Breast Cancer[J],2022,15.
APA	Xu, Lijun,Hu, Yaomin,&Liu, Wenwen.(2022).p Pyroptosis-Mediated Molecular Subtypes are Characterized by Distinct Tumor Microenvironment Infiltration Characteristics in Breast Cancer.JOURNAL OF INFLAMMATION RESEARCH,15.
MLA	Xu, Lijun,et al."p Pyroptosis-Mediated Molecular Subtypes are Characterized by Distinct Tumor Microenvironment Infiltration Characteristics in Breast Cancer".JOURNAL OF INFLAMMATION RESEARCH 15(2022).