干旱区生态环境知识资源中心(Arid): Sex Differences in Alzheimer's Disease Revealed by Free-Water Diffusion Tensor Imaging and Voxel-Based Morphometry

Arid

DOI	10.3233/JAD-210406
	Sex Differences in Alzheimer's Disease Revealed by Free-Water Diffusion Tensor Imaging and Voxel-Based Morphometry
	Bergamino, Maurizio; Keeling, Elizabeth G.; Baxter, Leslie C.; Sisco, Nicholas J.; Walsh, Ryan R.; Stokes, Ashley M.
通讯作者	Stokes, AM
来源期刊	JOURNAL OF ALZHEIMERS DISEASE
ISSN	1387-2877
EISSN	1875-8908
出版年	2022
卷号	85 期号:1
英文摘要	Background: Imaging biomarkers are increasingly used in Alzheimer's disease (AD), and the identification of sex differences using neuroimaging may provide insight into disease heterogeneity, progression, and therapeutic targets. Objective: The purpose of this study was to investigate differences in grey matter (GM) volume and white matter (WM) microstructural disorganization between males and females with AD using voxel-based morphometry (VBM) and free-water-corrected diffusion tensor imaging (FW-DTI). Methods: Data were downloaded from the OASIS-3 database, including 158 healthy control (HC; 86 females) and 46 mild AD subjects (24 females). VBM and FW-DTI metrics (fractional anisotropy (FA), axial and radial diffusivities (AxD and RD, respectively), and FW index) were compared using effect size for the main effects of group, sex, and their interaction. Results: Significant group and sex differences were observed, with no significant interaction. Post-hoc comparisons showed that AD is associated with reduced GM volume, reduced FW-FA, and higher FW-RD/FW-index, consistent with neurode-generation. Females in both groups exhibited higher GM volume than males, while FW-DTI metrics showed sex differences only in the AD group. Lower FW, lower FW-FA and higher FW-RD were observed in females relative to males in the AD group. Conclusion: The combination of VBM and DTI may reveal complementary sex-specific changes in GM and WM associated with AD and aging. Sex differences in GM volume were observed for both groups, while FW-DTI metrics only showed significant sex differences in the AD group, suggesting that WM tract disorganization may play a differential role in AD pathophysiology between females and males.
英文关键词	Alzheimer's disease diffusion tensor MRI free-water DTI sexual dimorphism voxel-based morphometry
类型	Article
语种	英语
开放获取类型	Green Accepted
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000740947000033
WOS关键词	WHITE-MATTER DEGENERATION ; HUMAN CEREBRAL-CORTEX ; GENDER-DIFFERENCES ; CORPUS-CALLOSUM ; VERBAL MEMORY ; FEMALE ADVANTAGE ; INCIDENCE RATES ; APOE EPSILON-4 ; HUMAN BRAIN ; AGE
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376733
推荐引用方式 GB/T 7714	Bergamino, Maurizio,Keeling, Elizabeth G.,Baxter, Leslie C.,et al. Sex Differences in Alzheimer's Disease Revealed by Free-Water Diffusion Tensor Imaging and Voxel-Based Morphometry[J],2022,85(1).
APA	Bergamino, Maurizio,Keeling, Elizabeth G.,Baxter, Leslie C.,Sisco, Nicholas J.,Walsh, Ryan R.,&Stokes, Ashley M..(2022).Sex Differences in Alzheimer's Disease Revealed by Free-Water Diffusion Tensor Imaging and Voxel-Based Morphometry.JOURNAL OF ALZHEIMERS DISEASE,85(1).
MLA	Bergamino, Maurizio,et al."Sex Differences in Alzheimer's Disease Revealed by Free-Water Diffusion Tensor Imaging and Voxel-Based Morphometry".JOURNAL OF ALZHEIMERS DISEASE 85.1(2022).