干旱区生态环境知识资源中心(Arid): Anticancer Activity of Moringa peregrina (Forssk.) Fiori.: A Native Plant in Traditional Herbal Medicine of the United Arab Emirates

Arid

DOI	10.3390/horticulturae8010037
	Anticancer Activity of Moringa peregrina (Forssk.) Fiori.: A Native Plant in Traditional Herbal Medicine of the United Arab Emirates
	Al Kaabi, Salama Khamis Sultan; Senthilkumar, Annadurai; Kizhakkayil, Jaleel; Alyafei, Mohammed Abdul Muhsen; Kurup, Shyam Sreedhara; Al Dhaheri, Ayesha S.; Jaleel, Abdul
通讯作者	Jaleel, A (corresponding author)，United Arab Emirates Univ, Dept Integrat Agr, Coll Agr & Vet Med, POB 15551, Al Ain, U Arab Emirates. ; Al Dhaheri, AS (corresponding author)，United Arab Emirates Univ, Dept Nutr & Hlth, Coll Med & Hlth Sci, POB 15551, Al Ain, U Arab Emirates.
来源期刊	HORTICULTURAE
EISSN	2311-7524
出版年	2022
卷号	8 期号:1
英文摘要	Moringa peregrina (Forssk.) Fiori. is a native desert tree growing in United Arab Emirates (UAE). The plant is being cultivated in many parts of UAE, owing to its uses in traditional medicinal and food systems. In the present study bioactivities of cultivated M. peregrina species samples are evaluated with cytotoxic studies in the human breast cancer cell line (MCF-7) and human colon adenocarcinoma cell line (Caco-2). Different extracts with hexane, chloroform, acetone and methanol were prepared from tubers, leaves and stem of M. peregrina for estimating their antioxidant contents and anticancer activities. The study was performed at different concentrations and all the extracts showed dose-depended response on both the cell lines. Among the extracts tested, the chloroform extract of stem showed remarkable anti-proliferative/cell death activity (IC50 = 45.53 mu g/mL of 48 h incubation and 33.32 mu g/mL of 72 h incubation) on MCF-7 cell lines. Whereas the same extract showed comparatively less activity (IC50 = 93.75 mu g/mL of 48 h incubation and 87.76 mu g/mL of 72 h incubation) on Caco-2 cell lines. The anti-proliferative effect of leaf extract with chloroform showed a drastic change in cell viability from 48 to 72 h incubation, in MCF-7 cells 220 to 87.5 mu g/mL and in Caco-2 cells 500.9 to 72.9 mu g/mL, respectively. Moreover, less than 200 mu g/mL of IC50 values reported in hexane extracts of tubers (188.6 mu g/mL for 48 h and 164.3 mu g/mL for 72 h), acetone extracts of tubers (167.4 mu g/mL for 72 h) and acetone extracts of stem (171.5 mu g/mL for 48 h and 101.7 mu g/mL for 72 h) on MCF-7 cells. PARP (Poly (ADP-ribose) polymerase) cleavage assay and DNA fragmentation assay performed to understand the cause of cell death. Treatment of extract on the normal fibroblast cell line required more concentration for cytotoxicity compared to the treatment on the cancer cells. This ability of the extract proved the anti-cancer property of the M. peregrina extract from the stem, tuber and leaves. The information provided in the present study enables further studies on the isolation and characterization of an anticancer molecule from the tubers of M. peregrina.
英文关键词	Moringa peregrina natural products cancer management breast cancer colon cancer
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000758554800001
WOS关键词	LEAF EXTRACTS ; CANCER CELLS ; ANTIOXIDANT ; PHOSPHORYLATION
WOS类目	Horticulture
WOS研究方向	Agriculture
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376689
作者单位	[Al Kaabi, Salama Khamis Sultan; Senthilkumar, Annadurai; Alyafei, Mohammed Abdul Muhsen; Kurup, Shyam Sreedhara; Jaleel, Abdul] United Arab Emirates Univ, Dept Integrat Agr, Coll Agr & Vet Med, POB 15551, Al Ain, U Arab Emirates; [Kizhakkayil, Jaleel; Al Dhaheri, Ayesha S.] United Arab Emirates Univ, Dept Nutr & Hlth, Coll Med & Hlth Sci, POB 15551, Al Ain, U Arab Emirates
推荐引用方式 GB/T 7714	Al Kaabi, Salama Khamis Sultan,Senthilkumar, Annadurai,Kizhakkayil, Jaleel,et al. Anticancer Activity of Moringa peregrina (Forssk.) Fiori.: A Native Plant in Traditional Herbal Medicine of the United Arab Emirates[J],2022,8(1).
APA	Al Kaabi, Salama Khamis Sultan.,Senthilkumar, Annadurai.,Kizhakkayil, Jaleel.,Alyafei, Mohammed Abdul Muhsen.,Kurup, Shyam Sreedhara.,...&Jaleel, Abdul.(2022).Anticancer Activity of Moringa peregrina (Forssk.) Fiori.: A Native Plant in Traditional Herbal Medicine of the United Arab Emirates.HORTICULTURAE,8(1).
MLA	Al Kaabi, Salama Khamis Sultan,et al."Anticancer Activity of Moringa peregrina (Forssk.) Fiori.: A Native Plant in Traditional Herbal Medicine of the United Arab Emirates".HORTICULTURAE 8.1(2022).