干旱区生态环境知识资源中心(Arid): Imaging of the nigrostriatal system for evaluating the preclinical phase of Parkinson's disease development: the utility of neuromelanin, diffusion MRI, and DAT-SPECT

Arid

DOI	10.1259/bjr.20210837
	Imaging of the nigrostriatal system for evaluating the preclinical phase of Parkinson's disease development: the utility of neuromelanin, diffusion MRI, and DAT-SPECT
	Takahashi, Hiroto; Kashiwagi, Nobuo; Arisawa, Atsuko; Matsuo, Chisato; Kato, Hiroki; Adachi, Hiroyoshi; Kajiyama, Yuta; Mochizuki, Hideki; Tomiyama, Noriyuki
通讯作者	Takahashi, H (corresponding author)，Osaka Univ, Div Hlth Sci, Grad Sch Med, Suita, Osaka, Japan. ; Takahashi, H (corresponding author)，Osaka Univ, Dept Diagnost & Intervent Radiol, Grad Sch Med, Osaka, Japan.
来源期刊	BRITISH JOURNAL OF RADIOLOGY
ISSN	0007-1285
EISSN	1748-880X
出版年	2022
卷号	95 期号:1130
英文摘要	Objective: To assess the utility of examining the nigrostriatal system with MRI arid dopamine transporter (DAT) imaging for evaluating the preclinical phase of Parkinson's disease (PD). Methods: The subjects were 32 patients with early PD and a history of probable rapid eye movement sleep behavior disorder (RBD; PD group), 15 patients with idiopathic RBD (RBD group), and 24 age-matched healthy controls (HC group) who underwent neuromelanin and diffusion tensor MRI for analysis of the substantia nigra pars compacta (SNpc), The RBD and PD groups underwent DAT imaging. In the RBD group, totals of 39 MRI and 27 DAT imaging examinations were obtained longitudinally. For each value, intergroup differences and receiver operating characteristic analysis for diagnostic performance were examined statistically. Results: The neuromelanin value was significantly lower and the diffusion tensor values except fractional anisotropy were significantly higher in the RBD and PD groups than in the HC group. The DAT specific binding ratio (SBR) was significantly lower in the PD group than in the RBD group. The areas under the receiver operating characteristic curves (AUCs) for neuromelanin/mean diffusivity value in the SNpc were 0.76/0.82 for diagnosing RBD and 0.83/0.80 for diagnosing PD. The area under the receiver operating characteristic curves for the SBR for discriminating PD from RBD was 0.87. Conclusion: MRI and DAT imaging may be useful for evaluating sequential nigrostriatal changes during the preclinical phase of PD. Advances in knowledge: MRI detects nigrostriatal changes in both RBD and early PD, and DAT imaging detects nigrostriatal changes during the transition to PD in RBD.
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000752778900020
WOS关键词	SLEEP BEHAVIOR DISORDER ; SUBSTANTIA-NIGRA ; DOPAMINE
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376642
作者单位	[Takahashi, Hiroto] Osaka Univ, Div Hlth Sci, Grad Sch Med, Suita, Osaka, Japan; [Takahashi, Hiroto; Arisawa, Atsuko; Matsuo, Chisato; Tomiyama, Noriyuki] Osaka Univ, Dept Diagnost & Intervent Radiol, Grad Sch Med, Osaka, Japan; [Kashiwagi, Nobuo] Osaka Univ, Dept Future Diagnost Radiol, Grad Sch Med, Osaka, Japan; [Kato, Hiroki] Osaka Univ, Dept Nucl Med & Tracer Kinet, Grad Sch Med, Osaka, Japan; [Adachi, Hiroyoshi] Osaka Univ, Dept Psychiat, Grad Sch Med, Osaka, Japan; [Kajiyama, Yuta; Mochizuki, Hideki] Osaka Univ, Dept Neurol, Grad Sch Med, Osaka, Japan
推荐引用方式 GB/T 7714	Takahashi, Hiroto,Kashiwagi, Nobuo,Arisawa, Atsuko,et al. Imaging of the nigrostriatal system for evaluating the preclinical phase of Parkinson's disease development: the utility of neuromelanin, diffusion MRI, and DAT-SPECT[J],2022,95(1130).
APA	Takahashi, Hiroto.,Kashiwagi, Nobuo.,Arisawa, Atsuko.,Matsuo, Chisato.,Kato, Hiroki.,...&Tomiyama, Noriyuki.(2022).Imaging of the nigrostriatal system for evaluating the preclinical phase of Parkinson's disease development: the utility of neuromelanin, diffusion MRI, and DAT-SPECT.BRITISH JOURNAL OF RADIOLOGY,95(1130).
MLA	Takahashi, Hiroto,et al."Imaging of the nigrostriatal system for evaluating the preclinical phase of Parkinson's disease development: the utility of neuromelanin, diffusion MRI, and DAT-SPECT".BRITISH JOURNAL OF RADIOLOGY 95.1130(2022).