Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.3389/fcimb.2021.822562 |
| Phages in the Gut Ecosystem | |
| Zuppi, Michele; Hendrickson, Heather L.; O'Sullivan, Justin M.; Vatanen, Tommi | |
| 通讯作者 | Vatanen, T (corresponding author)，Univ Auckland, Liggins Inst, Auckland, New Zealand. ; Vatanen, T (corresponding author)，Broad Inst MIT & Harvard, Cambridge, MA 02142 USA. |
| 来源期刊 | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
 |
| ISSN | 2235-2988 |
| 出版年 | 2022 |
| 卷号 | 11 |
| 英文摘要 | Phages, short for bacteriophages, are viruses that specifically infect bacteria and are the most abundant biological entities on earth found in every explored environment, from the deep sea to the Sahara Desert. Phages are abundant within the human biome and are gaining increasing recognition as potential modulators of the gut ecosystem. For example, they have been connected to gastrointestinal diseases and the treatment efficacy of Fecal Microbiota Transplant. The ability of phages to modulate the human gut microbiome has been attributed to the predation of bacteria or the promotion of bacterial survival by the transfer of genes that enhance bacterial fitness upon infection. In addition, phages have been shown to interact with the human immune system with variable outcomes. Despite the increasing evidence supporting the importance of phages in the gut ecosystem, the extent of their influence on the shape of the gut ecosystem is yet to be fully understood. Here, we discuss evidence for phage modulation of the gut microbiome, postulating that phages are pivotal contributors to the gut ecosystem dynamics. We therefore propose novel research questions to further elucidate the role(s) that they have within the human ecosystem and its impact on our health and well-being. |
| 英文关键词 | gut microbiome bacteriophage prophage microbial ecology metagenomics |
| 类型 | Review |
| 语种 | 英语 |
| 开放获取类型 | Green Published, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000745182500001 |
| WOS关键词 | ANTIBIOTIC-RESISTANCE GENES ; HOST PREDICTION ; DNA VIRUSES ; BACTERIOPHAGE ; MICROBIOTA ; DIVERSITY ; PROPHAGES ; VIROME ; INHIBITION ; EXPANSION |
| WOS类目 | Immunology ; Microbiology |
| WOS研究方向 | Immunology ; Microbiology |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/376622 |
| 作者单位 | [Zuppi, Michele; O'Sullivan, Justin M.; Vatanen, Tommi] Univ Auckland, Liggins Inst, Auckland, New Zealand; [Hendrickson, Heather L.] Massey Univ, Sch Nat & Computat Sci, Auckland, New Zealand; [O'Sullivan, Justin M.] Univ Auckland, Maurice Wilkins Ctr, Auckland, New Zealand; [O'Sullivan, Justin M.] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England; [Vatanen, Tommi] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA |
| 推荐引用方式 GB/T 7714 | Zuppi, Michele,Hendrickson, Heather L.,O'Sullivan, Justin M.,et al. Phages in the Gut Ecosystem[J],2022,11. |
| APA | Zuppi, Michele,Hendrickson, Heather L.,O'Sullivan, Justin M.,&Vatanen, Tommi.(2022).Phages in the Gut Ecosystem.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,11. |
| MLA | Zuppi, Michele,et al."Phages in the Gut Ecosystem".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 11(2022). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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