干旱区生态环境知识资源中心(Arid): Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts

Arid

DOI	10.15252/embr.202050851
	Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts
	Wang, Huimin; Jiang, Feng; Liu, Xiang; Liu, Qing; Fu, Yunyun; Li, Ran; Hou, Li; Zhang, Jie; He, Jing; Kang, Le
通讯作者	Kang, L (corresponding author)，Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China. ; Kang, L (corresponding author)，Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing, Peoples R China. ; Kang, L (corresponding author)，Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China. ; Kang, L (corresponding author)，Hebei Univ, Coll Life Sci, Baoding, Peoples R China.
来源期刊	EMBO REPORTS
ISSN	1469-221X
EISSN	1469-3178
出版年	2022
卷号	23 期号:3
英文摘要	Animal feeding, which directly affects growth and metabolism, is an important physiological process. However, the contribution of PIWI proteins and PIWI-interacting RNAs (piRNAs) to the regulatory mechanism of animal feeding is unknown. Here, we report a novel function of Piwi and piRNAs in regulating food intake in locusts. Our study shows that the locust can serve as a representative species for determining PIWI function in insects. Knockdown of Piwi1 expression suppresses anabolic processes and reduces food consumption and body weight. The reduction in food intake by knockdown of Piwi1 expression results from decreased expression of neuropeptide NPF1 in a piRNA-dependent manner. Mechanistically, intronic piRNAs might enhance RNA splicing of NPF1 by preventing hairpin formation at the branch point sites. These results suggest a novel nuclear PIWI/piRNA-mediated mechanism that controls food intake in the locust nervous system.
英文关键词	feeding neuropeptide piRNA PIWI protein
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000738969900001
WOS关键词	SMALL NONCODING RNAS ; GENE-EXPRESSION ; FEEDING-BEHAVIOR ; MESSENGER-RNAS ; DESERT LOCUST ; PIWI PROTEINS ; PHASE-CHANGES ; PIRNA ; DROSOPHILA ; GENOME
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376617
作者单位	[Wang, Huimin; Jiang, Feng; Li, Ran; Zhang, Jie; Kang, Le] Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China; [Wang, Huimin; Jiang, Feng; Kang, Le] Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing, Peoples R China; [Liu, Xiang; Liu, Qing; Hou, Li; He, Jing; Kang, Le] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China; [Liu, Qing] Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China; [Fu, Yunyun; Kang, Le] Hebei Univ, Coll Life Sci, Baoding, Peoples R China
推荐引用方式 GB/T 7714	Wang, Huimin,Jiang, Feng,Liu, Xiang,et al. Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts[J],2022,23(3).
APA	Wang, Huimin.,Jiang, Feng.,Liu, Xiang.,Liu, Qing.,Fu, Yunyun.,...&Kang, Le.(2022).Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts.EMBO REPORTS,23(3).
MLA	Wang, Huimin,et al."Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts".EMBO REPORTS 23.3(2022).