干旱区生态环境知识资源中心(Arid): High prevalence of urinary schistosomiasis in a desert population: results from an exploratory study around the Ounianga lakes in Chad

Arid

DOI	10.1186/s40249-021-00930-4
	High prevalence of urinary schistosomiasis in a desert population: results from an exploratory study around the Ounianga lakes in Chad
	Moser, Wendelin; Batil, Annour Adoum; Ott, Rebekka; Abderamane, Moussa; Clements, Ruth; Wampfler, Rahel; Poppert, Sven; Steinmann, Peter; Allan, Fiona; Greter, Helena
通讯作者	Greter, H (corresponding author)，Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
来源期刊	INFECTIOUS DISEASES OF POVERTY
ISSN	2095-5162
EISSN	2049-9957
出版年	2022
卷号	11 期号:1
英文摘要	Background: Researching a water-borne disease in the middle of the Sahara desert might not seem the most relevant concern. However, nomadic Sahelian pastoralists health concerns regarding their livestock and anecdotal reports about trematode infections of Fasciola spp. and Schistosoma spp. in desert-raised animals justified an exploratory study focusing on the lakes of Ounianga in Northern Chad. The aim was to test whether trematode parasites such as Schistosoma spp. occur in human populations living around the Sahara desert lakes of Ounianga Kebir and Ounianga Serir in northern Chad. Methods: The study was carried out in January 2019 and comprised of three components. First, a cross sectional survey based on a random sample drawn from the population to detect infections with S. haematobium and S. mansoni; second, focus group discussions exploring disease priorities, access to health and health seeking behaviour; and third, surveying water contact sites for intermediate host snails. Samples of trematode parasites and snails were confirmed on species level by molecular genetic methods. For parasitological and malacological surveys descriptive statistics were performed. Qualitative data analysis included the full review of all transcripts, followed by a descriptive and explorative thematic analysis. Results: Among 258 participants, the overall S. haematobium prevalence using urine filtration was 39.2% [95% confidence interval (CI): 33.5-45.1%], with 51.5% of the infected suffering from heavy infection. The intermediate host snail of S. haematobium (Bulinus truncatus) occurred at water contact sites near both study villages, revealing the potential for local transmission. Although a positive S. mansoni point-of-care circulating cathodic antigen (POC-CCA) test result was obtained from 8.6% (95% CI 5.7-12.8%) of the samples, no intermediate host snails of S. mansoni were found, and the relevance of S. mansoni remains uncertain. Qualitative findings underline the importance of morbidity caused by urinary schistosomiasis, and the lack of access to diagnostics and treatment as a major health concern. Conclusions: This research revealed a high prevalence of urinary schistosomiasis in the population living around the lakes of Ounianga in the Sahara, a United Nations Educational, Scientific and Cultural Organization (UNESCO) world heritage site in Chad. Despite the high public health importance of the associated morbidity expressed by the population, there is no access to diagnostics and treatment. Further work is needed to develop and test a contextadapted intervention.
英文关键词	Bulinus truncatus Chad Malacology Ounianga POC-CCA Prevalence Sahara Schistosoma bovis Schistosoma haematobium Schistosomiasis
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000739961800001
WOS关键词	HEALTH ; INFECTIONS ; DIAGNOSIS ; MANSONI ; SNAILS ; SAHEL
WOS类目	Infectious Diseases ; Parasitology ; Tropical Medicine
WOS研究方向	Infectious Diseases ; Parasitology ; Tropical Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376597
作者单位	[Moser, Wendelin; Ott, Rebekka; Wampfler, Rahel; Poppert, Sven; Steinmann, Peter; Greter, Helena] Swiss Trop & Publ Hlth Inst, Basel, Switzerland; [Moser, Wendelin; Ott, Rebekka; Wampfler, Rahel; Poppert, Sven; Steinmann, Peter; Greter, Helena] Univ Basel, Basel, Switzerland; [Batil, Annour Adoum] Inst Rech Elevage Dev, Ndjamena, Chad; [Abderamane, Moussa] Univ Ndjamena, Dept Geol, Ndjamena, Chad; [Clements, Ruth; Allan, Fiona] Nat Hist Museum, Dept Life Sci, London, England
推荐引用方式 GB/T 7714	Moser, Wendelin,Batil, Annour Adoum,Ott, Rebekka,et al. High prevalence of urinary schistosomiasis in a desert population: results from an exploratory study around the Ounianga lakes in Chad[J],2022,11(1).
APA	Moser, Wendelin.,Batil, Annour Adoum.,Ott, Rebekka.,Abderamane, Moussa.,Clements, Ruth.,...&Greter, Helena.(2022).High prevalence of urinary schistosomiasis in a desert population: results from an exploratory study around the Ounianga lakes in Chad.INFECTIOUS DISEASES OF POVERTY,11(1).
MLA	Moser, Wendelin,et al."High prevalence of urinary schistosomiasis in a desert population: results from an exploratory study around the Ounianga lakes in Chad".INFECTIOUS DISEASES OF POVERTY 11.1(2022).