干旱区生态环境知识资源中心(Arid): Fighting in a wasteland: deleterious metabolites and antitumor immunity

Arid

DOI	10.1172/JCI148549
	Fighting in a wasteland: deleterious metabolites and antitumor immunity
	Watson, McLane J.; Delgoffe, Greg M.
通讯作者	Delgoffe, GM (corresponding author)，Univ Pittsburgh, UPMC Hillman Canc Ctr, Dept Immunol, 5117 Ctr Ave,Ste 2-26b, Pittsburgh, PA 15232 USA.
来源期刊	JOURNAL OF CLINICAL INVESTIGATION
ISSN	0021-9738
EISSN	1558-8238
出版年	2022
卷号	132 期号:2
英文摘要	As cancers progress, they produce a local environment that acts to redirect, paralyze, exhaust, or otherwise evade immune detection and destruction. The tumor microenvironment (TME) has long been characterized as a metabolic desert, depleted of essential nutrients such as glucose, oxygen, and amino acids, that starves infiltrating immune cells and renders them dysfunctional. While not incorrect, this perspective is only half the picture. The TME is not a metabolic vacuum, only consuming essential nutrients and never producing by-products. Rather, the by-products of depleted nutrients, toxic metabolites in the TME such as lactic acid, kynurenine, ROS, and adenosine, play an important role in shaping immune cell function and cannot be overlooked in cancer immunotherapy. Moreover, while the metabolic landscape is distinct, it is not unique, as these toxic metabolites are encountered in non-tumor tissues, where they evolutionarily shape immune cells and their response. In this Review, we discuss how depletion of essential nutrients and production of toxic metabolites shape the immune response within the TME and how toxic metabolites can be targeted to improve current cancer immunotherapies.
类型	Review
语种	英语
开放获取类型	Green Published, hybrid
收录类别	SCI-E
WOS记录号	WOS:000747836200005
WOS关键词	REGULATORY T-CELLS ; INDOLEAMINE 2,3-DIOXYGENASE ; GENE-EXPRESSION ; LACTIC-ACID ; TRYPTOPHAN 2,3-DIOXYGENASE ; TUMOR MICROENVIRONMENT ; TOPICAL APPLICATION ; EFFECTOR FUNCTIONS ; IFN-GAMMA ; CANCER
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376541
作者单位	[Watson, McLane J.; Delgoffe, Greg M.] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15260 USA; [Watson, McLane J.; Delgoffe, Greg M.] UPMC Hillman Canc Ctr, Tumor Microenvironm Ctr, Canc Immunol & Immunotherapy Program, Pittsburgh, PA USA
推荐引用方式 GB/T 7714	Watson, McLane J.,Delgoffe, Greg M.. Fighting in a wasteland: deleterious metabolites and antitumor immunity[J],2022,132(2).
APA	Watson, McLane J.,&Delgoffe, Greg M..(2022).Fighting in a wasteland: deleterious metabolites and antitumor immunity.JOURNAL OF CLINICAL INVESTIGATION,132(2).
MLA	Watson, McLane J.,et al."Fighting in a wasteland: deleterious metabolites and antitumor immunity".JOURNAL OF CLINICAL INVESTIGATION 132.2(2022).