干旱区生态环境知识资源中心(Arid): The Prognostic Value of FoxP3+Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+Cytotoxic T Cell Density

Arid

DOI	10.3389/fimmu.2022.781222
	The Prognostic Value of FoxP3+Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+Cytotoxic T Cell Density
	Schnellhardt, Soeren; Hirneth, Johannes; Buettner-Herold, Maike; Daniel, Christoph; Haderlein, Marlen; Hartmann, Arndt; Fietkau, Rainer; Distel, Luitpold
通讯作者	Distel, L (corresponding author)，Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Dept Radiat Oncol, Erlangen, Germany. ; Distel, L (corresponding author)，Comprehens Canc Ctr Erlangen Europa Metropolreg N, Erlangen, Germany.
来源期刊	FRONTIERS IN IMMUNOLOGY
ISSN	1664-3224
出版年	2022
卷号	13
英文摘要	Tumour-infiltrating FoxP3+ regulatory T cells have been identified as both positive and negative prognostic factors in colorectal cancer (CRC) and rectal cancer (RC). In this study we investigated whether immune phenotypes, defined by CD8+ cytotoxic T cell density, may influence the prognostic association of FoxP3+ T cell densities in RC. Tissue microarrays from 154 rectal cancer resections were immunohistochemically double stained for CD8 and FoxP3. CD8+ and FoxP3+ cell densities were measured in the stromal and intraepithelial compartment. Stromal FoxP3+ cell densities were not associated with 10-year overall survival (OS). In the immune-desert phenotype, defined by very low stromal CD8+ cell density, a high density of stromal FoxP3+ T cells displayed a tendency towards an association with decreased 10-year OS (p = 0.179). In inflamed tumours, defined by high intraepithelial CD8+ T cell infiltration, the opposite was the case and high stromal FoxP3+ T cell densities were a positive prognostic factor (p = 0.048). Additionally, patients with an increased FoxP3/CD8 cell density ratio demonstrated a strong trend towards decreased 10-year OS (p = 0.066). These contrasting findings suggest functional heterogeneity within the group of FoxP3+ T cells. They are consistent with experimental studies which reported suppressive and non-suppressive populations of FoxP3+ T cells in CRC. Furthermore, our study demonstrates that CD8 immunohistochemistry may act as an instrument to identify tumours infiltrated by possibly functionally differing FoxP3+ T cell subtypes.
英文关键词	Foxp3 CD8 regulatory T cells rectal cancer tumour-infiltrating lymphocytes TILs immune phenotypes prognosis
类型	Article
语种	英语
开放获取类型	Green Submitted, Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000752083400001
WOS关键词	NEOADJUVANT CHEMORADIOTHERAPY ; TUMOR INFILTRATION ; EXPRESSION ; SURVIVAL
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376518
作者单位	[Schnellhardt, Soeren; Hirneth, Johannes; Haderlein, Marlen; Fietkau, Rainer; Distel, Luitpold] Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Dept Radiat Oncol, Erlangen, Germany; [Schnellhardt, Soeren; Hirneth, Johannes; Buettner-Herold, Maike; Daniel, Christoph; Haderlein, Marlen; Hartmann, Arndt; Fietkau, Rainer; Distel, Luitpold] Comprehens Canc Ctr Erlangen Europa Metropolreg N, Erlangen, Germany; [Buettner-Herold, Maike; Daniel, Christoph] Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Dept Nephropathol, Inst Pathol, Erlangen, Germany; [Hartmann, Arndt] Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Inst Pathol, Erlangen, Germany
推荐引用方式 GB/T 7714	Schnellhardt, Soeren,Hirneth, Johannes,Buettner-Herold, Maike,et al. The Prognostic Value of FoxP3+Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+Cytotoxic T Cell Density[J],2022,13.
APA	Schnellhardt, Soeren.,Hirneth, Johannes.,Buettner-Herold, Maike.,Daniel, Christoph.,Haderlein, Marlen.,...&Distel, Luitpold.(2022).The Prognostic Value of FoxP3+Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+Cytotoxic T Cell Density.FRONTIERS IN IMMUNOLOGY,13.
MLA	Schnellhardt, Soeren,et al."The Prognostic Value of FoxP3+Tumour-Infiltrating Lymphocytes in Rectal Cancer Depends on Immune Phenotypes Defined by CD8+Cytotoxic T Cell Density".FRONTIERS IN IMMUNOLOGY 13(2022).