干旱区生态环境知识资源中心(Arid): Rapid Screening and Confirmation of 108 Kinds of Veterinary Drug Residues in Livestock and Poultry Meat by Solid Phase Extraction Purification and Liquid Chromatography Coupled with Quadrupole/ Orbitrap Mass Spectrometry

Arid

DOI	10.19756/j.issn.0253-3820.211059
	Rapid Screening and Confirmation of 108 Kinds of Veterinary Drug Residues in Livestock and Poultry Meat by Solid Phase Extraction Purification and Liquid Chromatography Coupled with Quadrupole/ Orbitrap Mass Spectrometry
	Tian-Rong, G. U. O.; Yu-Ping, W. A. N.; Li, S. U. N.; Mei, Y. E.; Sen, X. U.; Shi-He, H. A. N.; Wen-Lin, W. U.
通讯作者	Wen-Lin, W
来源期刊	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN	0253-3820
EISSN	1872-2040
出版年	2022
卷号	50 期号:2 页码:271-277
英文摘要	An analytical strategy for simultaneous and rapid screening of 108 kinds of veterinary drug residues in livestock and poultry meat was established by using solid-phase extraction (SPE) to reduce impurity interference in samples and based on ultra-high performance liquid chromatography-quadrupole/ orbitrap high resolution mass spectrometry (UHPLC-Q/Orbitrap HRMS). The homogenized samples were extracted by 80% acetonitrile aqueous solution ( containing 0. 2% formic acid), purified by Oasis PRiME HLB solid phase extraction column, and redissolved by nitrogen blowing. The target analytes were separated from the samples by an Agilent Eclipse plus C18(3. 0 mm x 150 mm, 1. 8 mu m) chromatographic column, with acetonitrile and 0. 1% acetic acid-ammonium formate (20 mmol/L) aqueous solution system as the mobile phase in gradient elution. Under the heated electrospray ionization positive and negative ions simultaneous scan mode, the target analytes were analyzed by the full scan of primary mass spectrometry plus data-dependent secondary mass spectrometry (Full MS/ dd-MS2), and quantitatively detected by a matrix matching quantitative standard curve method. The results showed that 108 kinds of veterinary drugs had a good linear relationship in the range of 0. 5-2000 ng/mL, and the correlation coefficients (R) were over 0. 9950. The limits of detection (LODs ) were 0. 1-20 mu g/kg, and the limits of quantitation (LOQs) were 0.2-100 mu g/kg. The standard recoveries of different livestock and poultry meat under three levels of addition (n = 6) were 68. 7%-112. 5% , and the relative standard deviation (RSDs) were 0. 9%-9. 7%. This method was simple, rapid and accurate, with wide coverage and high-throughput, and was suitable for rapid screening and confirmative analysis of veterinary drug residues in livestock and poultry meat.
英文关键词	Livestock and poultry meat Veterinary drug residues Solid phase extraction purification Quadrupole orbitrap mass spectrometry Rapid screening
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000748379400001
WOS关键词	PESTICIDE-RESIDUES ; FISH-TISSUES
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376475
推荐引用方式 GB/T 7714	Tian-Rong, G. U. O.,Yu-Ping, W. A. N.,Li, S. U. N.,et al. Rapid Screening and Confirmation of 108 Kinds of Veterinary Drug Residues in Livestock and Poultry Meat by Solid Phase Extraction Purification and Liquid Chromatography Coupled with Quadrupole/ Orbitrap Mass Spectrometry[J],2022,50(2):271-277.
APA	Tian-Rong, G. U. O..,Yu-Ping, W. A. N..,Li, S. U. N..,Mei, Y. E..,Sen, X. U..,...&Wen-Lin, W. U..(2022).Rapid Screening and Confirmation of 108 Kinds of Veterinary Drug Residues in Livestock and Poultry Meat by Solid Phase Extraction Purification and Liquid Chromatography Coupled with Quadrupole/ Orbitrap Mass Spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,50(2),271-277.
MLA	Tian-Rong, G. U. O.,et al."Rapid Screening and Confirmation of 108 Kinds of Veterinary Drug Residues in Livestock and Poultry Meat by Solid Phase Extraction Purification and Liquid Chromatography Coupled with Quadrupole/ Orbitrap Mass Spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 50.2(2022):271-277.