干旱区生态环境知识资源中心(Arid): Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses

Arid

DOI	10.1158/0008-5472.CAN-21-0253
	Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses
	Moore, Jade; Ma, Lin; Lazar, Ann A.; Barcellos-Hoff, Mary Helen
通讯作者	Barcellos-Hoff, MH (corresponding author)，Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, Sch Med, Dept Radiat Oncol, 2340 Sutter St, San Francisco, CA 94143 USA.
来源期刊	CANCER RESEARCH
ISSN	0008-5472
EISSN	1538-7445
出版年	2022
卷号	82 期号:3 页码:365-376
英文摘要	In breast cancer, the type and distribution of infiltrating immune cells are associated with clinical outcome. Moreover, cancers with abundant tumor-infiltrating lymphocytes (TIL) are more likely to respond to immunotherapy, whereas those in which CD8 thorn T cells are completely absent (deserts) or excluded are less likely to respond. Detailed understanding of this biology is limited by a lack of preclinical breast cancer models that recapitulate TIL distributions and their associated biology. Here we established mammary tumor-derived transplants (mTDT) from 12 Trp53-null mammary tumors in syngeneic BALB/cJ mice and examined the stability of their growth rate, TIL distribution, and transcriptomic profiles. All mTDTs were estrogen receptor negative. Half of the parental tumors were classified as infiltrated, and the rest were divided between excluded and desert phenotypes. After two orthotopic passages, most (70%) mTDT from infiltrated parents recapitulated this pattern, whereas the desert or excluded parental patterns were
类型	Article
语种	英语
开放获取类型	Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000752279200001
WOS关键词	SUPPRESSOR GENE ; RADIATION ACTS ; MICROENVIRONMENT ; XENOGRAFTS ; JUVENILE ; SUBTYPES ; ADULT ; ARISE ; MICE
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376462
作者单位	[Moore, Jade; Ma, Lin; Barcellos-Hoff, Mary Helen] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA; [Moore, Jade; Ma, Lin; Barcellos-Hoff, Mary Helen] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA; [Lazar, Ann A.] Univ Calif San Francisco, Sch Dent, Dept Oral Epidemiol, San Francisco, CA USA; [Lazar, Ann A.] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA; [Ma, Lin] Shenzhen Univ, Dept Stomatol, Gen Hosp, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Moore, Jade,Ma, Lin,Lazar, Ann A.,et al. Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses[J],2022,82(3):365-376.
APA	Moore, Jade,Ma, Lin,Lazar, Ann A.,&Barcellos-Hoff, Mary Helen.(2022).Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses.CANCER RESEARCH,82(3),365-376.
MLA	Moore, Jade,et al."Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses".CANCER RESEARCH 82.3(2022):365-376.