干旱区生态环境知识资源中心(Arid): Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer

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DOI	10.3389/fcell.2022.785058
	Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer
	Dong, Menglu; Shen, Wenzhuang; Yang, Guang; Yang, Zhifang; Li, Xingrui
通讯作者	Yang, ZF ; Li, XR (corresponding author)，Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Thyroid & Breast Surg, Wuhan, Peoples R China.
来源期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
出版年	2022
卷号	10
英文摘要	Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer (BC). However, the potential roles of m6A modification in the tumor microenvironment (TME) of BC remain unclear. For addressing this issue, we comprehensively analyzed the m6A modification patterns in 983 samples and correlated these modification patterns with TME immune cell infiltration, based on 23 kinds of m6A regulators. Principal component analysis (PCA) was used to construct the m6A scoring system to quantify the modification pattern of m6A of BC individuals. Consequently, three different m6A modification patterns were identified, and the infiltrating characteristics of TME cells were consistent with the three immune phenotypes, including immune rejection, immune inflammation, and immune desert. Besides, our analysis showed that the prognosis of patients could be predicted by evaluating the m6A modification pattern in the tumor. The low m6Ascore corresponded to increased mutation burden and immune activation, while stroma activation and lack of immune infiltration were observed in high m6Ascore subtypes. In addition, a low m6Ascore was associated with enhanced response to anti-PD-1/PD-L1 immunotherapy. In conclusion, the m6A modification pattern was closely related to the BC immune landscape. This well-validated score model of the m6A modification patterns will provide a valuable tool to depict the tumor immune state and guide effective tumor immunotherapy for combating BC.
英文关键词	M6A tumor microenvironment breast cancer immunotherapy mutation burden
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000757196500001
WOS关键词	EXPRESSION ; BLOCKADE ; READERS ; WRITERS ; CELLS
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376445
作者单位	[Dong, Menglu; Shen, Wenzhuang; Yang, Zhifang; Li, Xingrui] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Thyroid & Breast Surg, Wuhan, Peoples R China; [Yang, Guang] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Thorac Surg, Tongji Med Coll, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Dong, Menglu,Shen, Wenzhuang,Yang, Guang,et al. Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer[J],2022,10.
APA	Dong, Menglu,Shen, Wenzhuang,Yang, Guang,Yang, Zhifang,&Li, Xingrui.(2022).Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10.
MLA	Dong, Menglu,et al."Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022).