干旱区生态环境知识资源中心(Arid): m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Cell-Infiltration Characterization in Head and Neck Cancer

Arid

DOI	10.3389/fcell.2021.803141
	m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Cell-Infiltration Characterization in Head and Neck Cancer
	Yang, Qinghui; Xu, Feng; Jian, Aiwen; Yu, Hongmei; Ye, Tao; Hu, Weiqi
通讯作者	Ye, T (corresponding author)，Fudan Univ, Zhongshan Hosp, Minhang Branch, Dept Oncol, Shanghai, Peoples R China. ; Ye, T (corresponding author)，Fudan Univ, Minhang Hosp, Key Lab Whole Period Monitoring & Precise Interve, Shanghai, Peoples R China. ; Ye, T (corresponding author)，Fudan Univ, AHS, Shanghai, Peoples R China. ; Hu, WQ (corresponding author)，Fudan Univ, Zhongshan Hosp, Minhang Branch, Dept Otolaryngol, Shanghai, Peoples R China.
来源期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
出版年	2022
卷号	9
英文摘要	Background: Recently, RNA modifications have emerged as essential epigenetic regulators of gene expression. However, the mechanism of how RNA N-6-methyladenosine (m6A) modification interacts with tumor microenvironment (TME) infiltration remains obscure.Methods: A total of 876 head and neck cancer samples considering 21 m6A regulators were included and analyzed to determine the m6A modification patterns. These modification patterns were then correlated with TME immune cell-infiltrating characteristics. A scoring system, the m6Ascore, was constructed using principal component analysis algorithms to quantify m6A modification of tumors.Results: Three m6A modification patterns were identified, with TME infiltrating characteristics highly consistent with tumors with three distinct immune phenotypes, including immune-inflamed, immune-exclude, and immune-desert phenotypes. It was demonstrated that the identification of the m6A modification patterns via m6Ascore could predict tumor progression, subtypes, TME stromal activity, variation of relevant genes, and patient prognosis. Low m6Ascore, identified to be an inflamed phenotype, is found to be associated with low stroma activity and tumor mutation burden, high survival probability, increased tumor neoantigen burden, and enhanced response to anti-PD-1/L1 immunotherapy. The therapeutic advantages and clinical benefits of patients with low m6Ascore were further verified in two immunotherapy cohorts.Conclusion: This study identified the significant role that the m6A modification played in the formation of TME characteristics. A more comprehensive understanding of the m6A modification patterns and their correlation with TME infiltration will contribute to the discovery of immunotherapy strategies with better efficacy.
英文关键词	m6A methylation head and neck cancer bioinformatics tumor microenvironment
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000760694700001
WOS关键词	MESSENGER-RNA ; CARCINOMA ; DIAGNOSIS ; MICRORNAS ; RECURRENT ; PROTEIN
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376320
作者单位	[Yang, Qinghui; Yu, Hongmei; Ye, Tao] Fudan Univ, Zhongshan Hosp, Minhang Branch, Dept Oncol, Shanghai, Peoples R China; [Yang, Qinghui; Yu, Hongmei; Ye, Tao] Fudan Univ, Minhang Hosp, Key Lab Whole Period Monitoring & Precise Interve, Shanghai, Peoples R China; [Yang, Qinghui; Yu, Hongmei; Ye, Tao] Fudan Univ, AHS, Shanghai, Peoples R China; [Xu, Feng] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Nucl Med, Sch Med, Shanghai, Peoples R China; [Jian, Aiwen] Shandong Univ, Sch Basic Med Sci, Jinan, Peoples R China; [Hu, Weiqi] Fudan Univ, Zhongshan Hosp, Minhang Branch, Dept Otolaryngol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yang, Qinghui,Xu, Feng,Jian, Aiwen,et al. m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Cell-Infiltration Characterization in Head and Neck Cancer[J],2022,9.
APA	Yang, Qinghui,Xu, Feng,Jian, Aiwen,Yu, Hongmei,Ye, Tao,&Hu, Weiqi.(2022).m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Cell-Infiltration Characterization in Head and Neck Cancer.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9.
MLA	Yang, Qinghui,et al."m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Cell-Infiltration Characterization in Head and Neck Cancer".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2022).