干旱区生态环境知识资源中心(Arid): Phenolic composition, antioxidant and enzyme inhibitory activities of Parkia biglobosa (Jacq.) Benth., Tithonia diversifolia (Hemsl) A. Gray, and Crossopteryx febrifuga (Afzel.) Benth

Arid

DOI	10.1016/j.arabjc.2021.103675
	Phenolic composition, antioxidant and enzyme inhibitory activities of Parkia biglobosa (Jacq.) Benth., Tithonia diversifolia (Hemsl) A. Gray, and Crossopteryx febrifuga (Afzel.) Benth
	Tamfu, Alfred Ngenge; Roland, Ndoubalem; Mfifen, Aristide Munvera; Kucukaydin, Selcuk; Gaye, Monde; Botezatu, Andreea Veronica; Duru, Mehmet Emin; Dinica, Rodica Mihaela
通讯作者	Tamfu, AN (corresponding author)，Univ Ngaoundere, Sch Chem Engn & Mineral Ind, Dept Chem Engn, Ngaoundere 454, Cameroon. ; Tamfu, AN ; Dinica, RM (corresponding author)，Univ Galatzi, Fac Sci & Environm, Dept Chem Phys & Environm, 47 Domneasca Str, Galati 800008, Romania. ; Tamfu, AN (corresponding author)，Mugla Sitki Kocman Univ, Fac Sci, Dept Chem, TR-48000 Mugla, Turkey.
来源期刊	ARABIAN JOURNAL OF CHEMISTRY
ISSN	1878-5352
EISSN	1878-5379
出版年	2022
卷号	15 期号:4
英文摘要	Medicinal plants from Chad grow under special climatic conditions in between the equatorial forest of Central Africa and the desert of North Africa and are understudied. Three medicinal plants from Chad (T. diversifolia, P. Biglobosa and C. Febrifuga) were evaluated for their phenolic composition, antioxidant and enzyme inhibition activities. The total phenolic composition varied from 203.19 +/- 0.58 mg GAE/g DW in the ethyl acetate extract of P. biglobosa, to 56.41 +/- 0.89 mg GAE/g DW in the methanol extract of C. febrifuga while the total flavonoid content varied from 51.85 +/- 0.91 mg QE/g DW in the methanol extract of P. biglobosa to 08.56 +/- 0.25 mg QE/g DW in the methanol extract of C. febrifuga. HPLC-DAD revealed that rutin, gallic acid and protocatechuic acid were the most abundant phenolics in T. diversifolia, P. Biglobosa and C. Feb-rifuga respectively. The antioxidant activity assayed by five different methods revealed very good activity especially in the DPPH', ABTS'+ and CUPRAC assays where the extracts were more active than the standard compounds used. Good inhibition was exhibited against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with methanol (IC50: 15.63 +/- 0.72 mu g/mL), ethyl acetate (IC50: 16.20 +/- 0.67 mu g/mL) extracts of P. biglobosa, and methanol (IC50: 21.53 +/- 0.65 mu g/mL) and ethyl acetate (IC50: 30.81 +/- 0.48 mu g/mL) extracts of T. diversifolia showing higher inhibition than galantamine (IC50: 42.20 +/- 0.44 mu g/mL) against BChE. Equally, good inhibition was shown on a-amylase and a-glucosidase. On the a-glucosidase, the ethyl acetate (IC50 = 12.47 +/- 0.61 mu g/ mL) and methanol extracts (IC50 = 16.51 +/- 0.18 mu g/mL) of P. biglobosa showed higher activity compared to the standard acarbose (IC50 = 17.35 +/- 0.71 mu g/mL) and on a-amylase, the ethyl acet-ate (IC50 = 13.50 +/- 0.90 mu g/mL) and methanol (IC50 = 18.12 +/- 0.33 mu g/mL) extracts of P. biglo-bosa showed higher activity compared to acarbose (IC50 = 23.84 +/- 0.25 mu g/mL). The results indicate that these plants are good sources of antioxidant phenolics and can be used to manage oxidative stress linked illnesses such as Alzheimer's disease and diabetes. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
英文关键词	Tithonia diversifolia Parkia Biglobosa Crossopteryx febrifuga Antioxidant Anticholinesterase Alzheimer's disease a-Amylase inhibition a-Glucosidase inhibition Antidiabetic activity
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000745058200001
WOS关键词	OXIDATIVE STRESS ; NEURODEGENERATIVE DISEASES ; CONVERTING-ENZYME ; EXTRACT ; PLANTS ; ACETYLCHOLINESTERASE ; IDENTIFICATION ; CONSTITUENTS ; BARK
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/376201
作者单位	[Tamfu, Alfred Ngenge] Univ Ngaoundere, Sch Chem Engn & Mineral Ind, Dept Chem Engn, Ngaoundere 454, Cameroon; [Roland, Ndoubalem] Minist Natl Educ, Ndjamena, Chad; [Mfifen, Aristide Munvera] Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde 812, Cameroon; [Kucukaydin, Selcuk] Mugla Sitki Kocman Univ, Koycegiz Vocat Sch Hlth Serv, Dept Med Serv & Tech, TR-48800 Mugla, Turkey; [Gaye, Monde] Univ Ngaoundere, Fac Sci, Dept Chem, Ngaoundere, Cameroon; [Tamfu, Alfred Ngenge; Botezatu, Andreea Veronica; Dinica, Rodica Mihaela] Univ Galatzi, Fac Sci & Environm, Dept Chem Phys & Environm, 47 Domneasca Str, Galati 800008, Romania; [Tamfu, Alfred Ngenge; Duru, Mehmet Emin] Mugla Sitki Kocman Univ, Fac Sci, Dept Chem, TR-48000 Mugla, Turkey
推荐引用方式 GB/T 7714	Tamfu, Alfred Ngenge,Roland, Ndoubalem,Mfifen, Aristide Munvera,et al. Phenolic composition, antioxidant and enzyme inhibitory activities of Parkia biglobosa (Jacq.) Benth., Tithonia diversifolia (Hemsl) A. Gray, and Crossopteryx febrifuga (Afzel.) Benth[J],2022,15(4).
APA	Tamfu, Alfred Ngenge.,Roland, Ndoubalem.,Mfifen, Aristide Munvera.,Kucukaydin, Selcuk.,Gaye, Monde.,...&Dinica, Rodica Mihaela.(2022).Phenolic composition, antioxidant and enzyme inhibitory activities of Parkia biglobosa (Jacq.) Benth., Tithonia diversifolia (Hemsl) A. Gray, and Crossopteryx febrifuga (Afzel.) Benth.ARABIAN JOURNAL OF CHEMISTRY,15(4).
MLA	Tamfu, Alfred Ngenge,et al."Phenolic composition, antioxidant and enzyme inhibitory activities of Parkia biglobosa (Jacq.) Benth., Tithonia diversifolia (Hemsl) A. Gray, and Crossopteryx febrifuga (Afzel.) Benth".ARABIAN JOURNAL OF CHEMISTRY 15.4(2022).