干旱区生态环境知识资源中心(Arid): Mitochondrial genomes of the human pathogens Coccidioides immitis and Coccidioides posadasii

Arid

DOI	10.1093/g3journal/jkab132
	Mitochondrial genomes of the human pathogens Coccidioides immitis and Coccidioides posadasii
	Teixeira, Marcus de Melo; Lang, B. Franz; Matute, Daniel R.; Stajich, Jason E.; Barker, Bridget M.
通讯作者	Barker, BM (corresponding author)，No Arizona Univ, Pathogen & Microbiome Inst, Appl Res & Dev Bldg,1395 S Knoles Dr, Flagstaff, AZ 86011 USA.
来源期刊	G3-GENES GENOMES GENETICS
ISSN	2160-1836
出版年	2021
卷号	11 期号:7
英文摘要	Fungal mitochondrial genomes encode genes involved in crucial cellular processes, such as oxidative phosphorylation and mitochondrial translation, and the molecule has been used as a molecular marker for population genetics studies. Coccidioides immitis and C. posadasii are endemic fungal pathogens that cause coccidioidomycosis in arid regions across both American continents. To date, approximately 150 Coccidioides isolates have been sequenced to infer patterns of variation in nuclear genomes. However, less attention has been given to the mitochondrial genomes of Coccidioides. In this report, we describe the assembly and annotation of mitochondrial reference genomes for two representative strains of C. posadasii and C. immitis, as well as assess population variation among 77 selected genomes. The sizes of the circular-mapping molecules are 68.2 Kb in C. immitis and 75.1 Kb in C. posadasii. We identify 14 mitochondrial protein-coding genes common to most fungal mitochondria, which are largely syntenic across different populations and species of Coccidioides. Both Coccidioides species are characterized by a large number of group I and II introns, harboring twice the number of elements as compared to closely related Onygenales. The introns contain complete or truncated ORFs with high similarity to homing endonucleases of the LAGLIDADG and GIY-YIG families. Phylogenetic comparisons of mitochondrial and nuclear genomes show extensive phylogenetic discordance suggesting that the evolution of the two types of genetic material is not identical. This work represents the first assessment of mitochondrial genomes among isolates of both species of Coccidioides, and provides a foundation for future functional work.
英文关键词	Valley fever Coccidioides Onygenales coccidioidomycosis mitochondrial genomes phylogenetics fungal pathogen group I and II introns
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000735821500024
WOS关键词	INTRACELLULAR PARASITISM DRIVEN ; FATAL FUNGAL OUTBREAK ; VANCOUVER-ISLAND ; READ ALIGNMENT ; UNITED-STATES ; YEAST ; RECOMBINATION ; NUCLEAR ; INCOMPATIBILITY ; APPROXIMATION
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/375970
作者单位	[Teixeira, Marcus de Melo; Barker, Bridget M.] No Arizona Univ, Pathogen & Microbiome Inst, Appl Res & Dev Bldg,1395 S Knoles Dr, Flagstaff, AZ 86011 USA; [Teixeira, Marcus de Melo] Univ Brasilia DF, Fac Med, BR-70910330 Brasilia, DF, Brazil; [Lang, B. Franz] Univ Montreal, Dept Biochim, Robert Cedergren Ctr Bioinformat & Genom, Montreal, PQ H3C 3J7, Canada; [Matute, Daniel R.] Univ N Carolina, Biol Dept, Chapel Hill, NC 27599 USA; [Stajich, Jason E.] Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA; [Stajich, Jason E.] Univ Calif Riverside, Dept Microbiol & Plant Pathol, Riverside, CA 92521 USA
推荐引用方式 GB/T 7714	Teixeira, Marcus de Melo,Lang, B. Franz,Matute, Daniel R.,et al. Mitochondrial genomes of the human pathogens Coccidioides immitis and Coccidioides posadasii[J],2021,11(7).
APA	Teixeira, Marcus de Melo,Lang, B. Franz,Matute, Daniel R.,Stajich, Jason E.,&Barker, Bridget M..(2021).Mitochondrial genomes of the human pathogens Coccidioides immitis and Coccidioides posadasii.G3-GENES GENOMES GENETICS,11(7).
MLA	Teixeira, Marcus de Melo,et al."Mitochondrial genomes of the human pathogens Coccidioides immitis and Coccidioides posadasii".G3-GENES GENOMES GENETICS 11.7(2021).