干旱区生态环境知识资源中心(Arid): The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Serido, Rio Grande do Norte, Brazil

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DOI	10.1371/journal.pntd.0009919
	The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Serido, Rio Grande do Norte, Brazil
	Lima-Neiva, Vanessa; Toma, Helena Keiko; Abrantes Aguiar, Lucia Maria; Lopes, Catarina Macedo; Dias, Leticia Paschoaletto; Monte Goncalves, Teresa Cristina; Costa, Jane
通讯作者	Lima-Neiva, V (corresponding author)，Fiocruz MS, Inst Oswaldo Cruz, Lab Biodiversidade Entomol, Rio De Janeiro, RJ, Brazil.
来源期刊	PLOS NEGLECTED TROPICAL DISEASES
ISSN	1935-2735
出版年	2021
卷号	15 期号:11
英文摘要	An outbreak of Chagas disease, possibly involving its vector Triatoma brasiliensis brasiliensis, was identified in the state of Rio Grande do Norte (RN). Given the historical significance of this vector in public health, the study aimed to evaluate its role in the transmission dynamics of the protozoan Trypanosoma cruzi in an area undergoing desertification in the Serido ' region, RN, Brazil. We captured triatomines in sylvatic and anthropic ecotopes. Natural vector infection was determined using parasitological and molecular methods and we identified discrete typing units (DTUs) of T. cruzi by analyzing the COII gene of mtDNA, 24Sa rDNA, and mini-exon gene. Their blood meals sources were identified by amplification and sequencing of the mtDNA cytochrome b gene. A total of 952 T. b. brasiliensis were captured in peridomestic (69.9%) and sylvatic ecotopes (30.4%). A wide range of natural infection rates were observed in peridomestic (36.0% - 71.1%) and sylvatic populations (28.6% - 100.0%). We observed the circulation of TcI and TcII DTUs with a predominance of Tcl in sylvatic and peridomestic environments. Kerodon rupestris, rocky cavy (13/39), Homo sapiens, human (8/39), and Bos taurus, ox (6/39) were the most frequently detected blood meals sources. Thus, Triatoma b. brasiliensis is invading and colonizing the human dwellings. Furthermore, high levels of natural infection, coupled with the detection of TcI and TcII DTUs, and also the detection of K. rupestris and H. sapiens as blood meals sources of infected T. b. brasiliensis indicate a risk of T. cruzi transmission to human populations in areas undergoing desertification.
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000750643700008
WOS关键词	CHAGAS-DISEASE VECTOR ; SHERLOCKI HEMIPTERA REDUVIIDAE ; SPECIES COMPLEX ; RANGELI TEJERA ; POPULATIONS ; INFECTION ; IDENTIFICATION ; AMPLIFICATION ; REVALIDATION ; PHYLOGENY
WOS类目	Infectious Diseases ; Parasitology ; Tropical Medicine
WOS研究方向	Infectious Diseases ; Parasitology ; Tropical Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/375869
作者单位	[Lima-Neiva, Vanessa; Dias, Leticia Paschoaletto; Costa, Jane] Fiocruz MS, Inst Oswaldo Cruz, Lab Biodiversidade Entomol, Rio De Janeiro, RJ, Brazil; [Toma, Helena Keiko] Univ Fed Rio de Janeiro, Fac Farmacia, Lab Diagnost Mol & Hematol, Rio De Janeiro, RJ, Brazil; [Abrantes Aguiar, Lucia Maria] Secret Estado Saude Publ, Natal, RN, Brazil; [Lopes, Catarina Macedo; Monte Goncalves, Teresa Cristina] Fiocruz MS, Inst Oswaldo Cruz, Lab Interdisciplinar Vigilancia Entomol Diptera &, Rio De Janeiro, RJ, Brazil
推荐引用方式 GB/T 7714	Lima-Neiva, Vanessa,Toma, Helena Keiko,Abrantes Aguiar, Lucia Maria,et al. The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Serido, Rio Grande do Norte, Brazil[J],2021,15(11).
APA	Lima-Neiva, Vanessa.,Toma, Helena Keiko.,Abrantes Aguiar, Lucia Maria.,Lopes, Catarina Macedo.,Dias, Leticia Paschoaletto.,...&Costa, Jane.(2021).The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Serido, Rio Grande do Norte, Brazil.PLOS NEGLECTED TROPICAL DISEASES,15(11).
MLA	Lima-Neiva, Vanessa,et al."The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Serido, Rio Grande do Norte, Brazil".PLOS NEGLECTED TROPICAL DISEASES 15.11(2021).