干旱区生态环境知识资源中心(Arid): Factors Influencing Distribution of Coccidioides immitis in Soil, Washington State, 2016

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	Factors Influencing Distribution of Coccidioides immitis in Soil, Washington State, 2016
	Chow, Nancy A.; Kangiser, David; Gade, Lalitha; McCotter, Orion Z.; Hurst, Steven; Salamone, Amy; Wohrle, Ron; Clifford, Wayne; Kim, Sunkyung; Salah, Zainab; Oltean, Hanna N.; Plumlee, Geoffrey S.; Litvintseva, Anastasia P.
通讯作者	Litvintseva, AP (corresponding author)，Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA.
来源期刊	MSPHERE
EISSN	2379-5042
出版年	2021
卷号	6 期号:6
英文摘要	Coccidioides immitis and Coccidioides posadasii are causative agents of Valley fever, a serious fungal disease endemic to regions with hot, arid climate in the United States, Mexico, and Central and South America. The environmental niche of Coccidioides spp. is not well defined, and it remains unknown whether these fungi are primarily associated with rodents or grow as saprotrophs in soil. To better understand the environmental reservoir of these pathogens, we used a systematic soil sampling approach, quantitative PCR (qPCR), culture, whole-genome sequencing, and soil chemical analysis to identify factors associated with the presence of C. immitis at a known colonization site in Washington State linked to a human case in 2010. We found that the same strain colonized an area of over 46,000 m(2) and persisted in soil for over 6 years. No association with rodent burrows was observed, as C. immitis DNA was as likely to be detected inside rodent holes as it was in the surrounding soil. In addition, the presence of C. immitis DNA in soil was correlated with elevated levels of boron, calcium, magnesium, sodium, and silicon in soil leachates. We also observed differences in the microbial communities between C. immitis-positive and -negative soils. Our artificial soil inoculation experiments demonstrated that C. immitis can use soil as a sole source of nutrients. Taken together, these results suggest that soil parameters need to be considered when modeling the distribution of this fungus in the environment. IMPORTANCE Coccidioidomycosis is considered a highly endemic disease for which geographic range is likely to expand from climate change. A better understanding of the ecological niche of Coccidioides spp. is essential for generating accurate distribution maps and predicting future changes in response to the changing environment. Our study used a systematic sampling strategy, advanced molecular detection methods, and soil chemical analysis to identify environmental factors associated with the presence of C. immitis in soil. Our results demonstrate the fungus can colonize the same areas for years and is associated with chemical and microbiological soil characteristics. Our results suggest that in addition to climate parameters, soil characteristics need to be considered when building habitat distribution models for this pathogen.
英文关键词	Valley fever Coccidioides coccidioidomycosis
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000754554800013
WOS关键词	UNITED-STATES ; MOLECULAR-IDENTIFICATION ; ECOLOGY ; DATABASE ; CLIMATE
WOS类目	Microbiology
WOS研究方向	Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/375860
作者单位	[Chow, Nancy A.; Gade, Lalitha; McCotter, Orion Z.; Hurst, Steven; Litvintseva, Anastasia P.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA; [Kangiser, David; Salamone, Amy; Wohrle, Ron; Clifford, Wayne; Oltean, Hanna N.] Washington State Dept Hlth, Shoreline, WA USA; [Kim, Sunkyung; Salah, Zainab] Ctr Dis Control & Prevent, Surveillance Informat Management, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA; [Kim, Sunkyung; Salah, Zainab] Ctr Dis Control & Prevent, Stat Off, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA; [Plumlee, Geoffrey S.] US Geol Survey, 959 Natl Ctr, Reston, VA 22092 USA; [McCotter, Orion Z.] Oregon Hlth Author, Portland, OR USA
推荐引用方式 GB/T 7714	Chow, Nancy A.,Kangiser, David,Gade, Lalitha,et al. Factors Influencing Distribution of Coccidioides immitis in Soil, Washington State, 2016[J],2021,6(6).
APA	Chow, Nancy A..,Kangiser, David.,Gade, Lalitha.,McCotter, Orion Z..,Hurst, Steven.,...&Litvintseva, Anastasia P..(2021).Factors Influencing Distribution of Coccidioides immitis in Soil, Washington State, 2016.MSPHERE,6(6).
MLA	Chow, Nancy A.,et al."Factors Influencing Distribution of Coccidioides immitis in Soil, Washington State, 2016".MSPHERE 6.6(2021).