干旱区生态环境知识资源中心(Arid): Canine leishmaniosis in Tunisia: Growing prevalence, larger zones of infection

Arid

DOI	10.1371/journal.pntd.000999
	Canine leishmaniosis in Tunisia: Growing prevalence, larger zones of infection
	Bouattour, Ali; Amri, Amine; Belkhiria, Jaber Amine; Rhim, Adel; Fezaa, Ons; Gantier, Jean-Charles; M'ghirbi, Youmna
通讯作者	Bouattour, A (corresponding author)，Univ Tunis El Manar, Inst Pasteur Tunis, Lab Virus Vecteurs & Hotes LR201PT02, Tunis, Tunisia.
来源期刊	PLOS NEGLECTED TROPICAL DISEASES
ISSN	1935-2735
出版年	2021
卷号	15 期号:12
英文摘要	Background Discovered by Nicolle and Comte in 1908 in Tunisia, Leishmania infantum is an intracellular protozoan responsible for zoonotic canine leishmaniosis (CanL) and zoonotic human visceral leishmaniasis (HVL). It is endemic in several regions of the world, including Tunisia, with dogs considered as the main domestic reservoir. The geographic expansion of canine leishmaniosis (CanL) has been linked to global environmental changes that have affected the density and the distribution of its sand fly vectors. Methodology/Principal findings In this study, a cross-sectional epidemiological survey on CanL was carried out in 8 localities in 8 bioclimatic areas of Tunisia. Blood samples were taken from 317 dogs after clinical examination. Collected sera were tested by indirect fluorescent antibody test (IFAT; 1:80) for the presence of anti-Leishmania infantum antibodies. The overall seroprevalence was 58.3% (185/317). Among positive dogs, only 16.7% showed clinical signs suggestive of leishmaniosis. Seroprevalence rates varied from 6.8% to 84.6% and from 28% to 66% by bioclimatic zone and age group, respectively. Serological positivity was not statistically associated with gender. The presence of Leishmania DNA in blood, using PCR, revealed 21.2% (64/302) prevalence in dogs, which varied by bioclimatic zone (7.3% to 31%) and age group (7% to 25%). The entomological survey carried out in the studied localities showed 16 species of the two genera (Phlebotomus and Sergentomyia). P. perniciosus, P. papatasi, and P. perfiliewi were the most dominant species with relative abundances of 34.7%, 25% and 20.4%, respectively. Conclusions/Significance The present report suggests a significant increase of CanL in all bioclimatic areas in Tunisia and confirms the ongoing spread of the infection of dogs to the country's arid zone. Such an expansion of infection in dog population could be attributed to ecological, agronomic, social and climatic factors that affect the presence and density of the phlebotomine vectors.
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000750645700009
WOS关键词	ZOONOTIC CUTANEOUS LEISHMANIASIS ; VISCERAL LEISHMANIASIS ; INFANTUM INFECTION ; PHLEBOTOMUS-PERNICIOSUS ; VERTICAL TRANSMISSION ; NATURAL INFECTION ; BREEDING SITE ; ENDEMIC AREA ; DOGS ; FOCUS
WOS类目	Infectious Diseases ; Parasitology ; Tropical Medicine
WOS研究方向	Infectious Diseases ; Parasitology ; Tropical Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/375705
作者单位	[Bouattour, Ali; Amri, Amine; Rhim, Adel; Fezaa, Ons; M'ghirbi, Youmna] Univ Tunis El Manar, Inst Pasteur Tunis, Lab Virus Vecteurs & Hotes LR201PT02, Tunis, Tunisia; [Belkhiria, Jaber Amine] Univ Calif Davis, One Hlth Inst, Davis, CA 95616 USA; [Gantier, Jean-Charles] Univ Reims, Fac Pharm, Reims, France
推荐引用方式 GB/T 7714	Bouattour, Ali,Amri, Amine,Belkhiria, Jaber Amine,et al. Canine leishmaniosis in Tunisia: Growing prevalence, larger zones of infection[J],2021,15(12).
APA	Bouattour, Ali.,Amri, Amine.,Belkhiria, Jaber Amine.,Rhim, Adel.,Fezaa, Ons.,...&M'ghirbi, Youmna.(2021).Canine leishmaniosis in Tunisia: Growing prevalence, larger zones of infection.PLOS NEGLECTED TROPICAL DISEASES,15(12).
MLA	Bouattour, Ali,et al."Canine leishmaniosis in Tunisia: Growing prevalence, larger zones of infection".PLOS NEGLECTED TROPICAL DISEASES 15.12(2021).