干旱区生态环境知识资源中心(Arid): Analyte-Induced Desert Rose-like Ag Nanostructures for Surface-Enhanced Raman Scattering-Based Biomolecule Detection and Imaging

Arid

DOI	10.1021/acsami.1c18815
	Analyte-Induced Desert Rose-like Ag Nanostructures for Surface-Enhanced Raman Scattering-Based Biomolecule Detection and Imaging
	Na, Hee-Kyung; Ki, Jisun; Le, Minh-Uyen; Kim, Kyoung-Shim; Lee, Chul-Ho; Lee, Tae Geol; Wi, Jung-Sub
通讯作者	Lee, TG (corresponding author)，Korea Res Inst Stand & Sci KRISS, Ctr Nanobio Measurement, Daejeon 34113, South Korea. ; Lee, TG (corresponding author)，Univ Sci & Technol UST, Dept Nano Sci, Daejeon 34113, South Korea. ; Wi, JS (corresponding author)，Hanbat Natl Univ, Dept Mat Sci & Engn, Daejeon 34158, South Korea.
来源期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
EISSN	1944-8252
出版年	2021
卷号	13 期号:49
英文摘要	Biomolecule detection based on surface-enhanced Raman scattering (SERS) for application to biosensors and bio-imaging requires the fabrication of SERS nanoprobes that can generate strong Raman signals as well as surface modifications for analyte-specific recognition and binding. Such requirements lead to disadvantages in terms of reproducibility and practicality, and thus, it has been difficult to apply biomolecule detection utilizing the advantages of the SERS phenomenon to actual clinically relevant analysis. To achieve reproducible and practical SERS signal generation in a biomolecule-specific manner without requiring the synthesis of nanostructures and their related surface modification to introduce molecules for specific recognition, we developed a new type of SERS probe formed by enzyme reactions in the presence of Raman reporters. By forming unique plasmonic structures, our method achieves the detection of biomolecules on chips with uniform and stable signals over long periods. To test the proposed approach, we applied it to a SERS-based immunohistochemistry assay and found successful multiplexed protein detection in brain tissue from transgenic mice.
英文关键词	analyte-specific SERS nanoprobe formation multiplexed SERS imaging SERS immunohistochemistry desert rose-like Ag nanostructures SERS biosensor
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000752977200014
WOS关键词	SILVER NANOPARTICLES ; SERS ; SENSITIVITY ; PROBES
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Science & Technology - Other Topics ; Materials Science
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/375673
作者单位	[Na, Hee-Kyung; Ki, Jisun; Le, Minh-Uyen; Lee, Tae Geol] Korea Res Inst Stand & Sci KRISS, Ctr Nanobio Measurement, Daejeon 34113, South Korea; [Le, Minh-Uyen; Lee, Tae Geol] Univ Sci & Technol UST, Dept Nano Sci, Daejeon 34113, South Korea; [Kim, Kyoung-Shim; Lee, Chul-Ho] Korea Res Inst Biosci & Biotechnol KRIBB, Lab Anim Resource Ctr, Daejeon 34141, South Korea
推荐引用方式 GB/T 7714	Na, Hee-Kyung,Ki, Jisun,Le, Minh-Uyen,et al. Analyte-Induced Desert Rose-like Ag Nanostructures for Surface-Enhanced Raman Scattering-Based Biomolecule Detection and Imaging[J],2021,13(49).
APA	Na, Hee-Kyung.,Ki, Jisun.,Le, Minh-Uyen.,Kim, Kyoung-Shim.,Lee, Chul-Ho.,...&Wi, Jung-Sub.(2021).Analyte-Induced Desert Rose-like Ag Nanostructures for Surface-Enhanced Raman Scattering-Based Biomolecule Detection and Imaging.ACS APPLIED MATERIALS & INTERFACES,13(49).
MLA	Na, Hee-Kyung,et al."Analyte-Induced Desert Rose-like Ag Nanostructures for Surface-Enhanced Raman Scattering-Based Biomolecule Detection and Imaging".ACS APPLIED MATERIALS & INTERFACES 13.49(2021).