干旱区生态环境知识资源中心(Arid): Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS

Arid

DOI	10.1016/j.jpha.2021.01.002
	Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS
	Wang, Jingyuan; Qi, Likai; Hou, Chenzhi; Zhang, Tingting; Chen, Mengyi; Meng, Haitao; Su, Mengxiang; Xu, Hui; Hua, Zhendong; Wang, Youmei; Di, Bin
通讯作者	Di, B (corresponding author)，China Pharmaceut Univ, Dept Pharm, Nanjing 210009, Peoples R China. ; Hua, ZD ; Wang, YM (corresponding author)，Minist Publ Secur Peoples Republ China, Drug Control Informat & Technol Ctr, Beijing 100741, Peoples R China.
来源期刊	JOURNAL OF PHARMACEUTICAL ANALYSIS
ISSN	2095-1779
EISSN	2214-0883
出版年	2021
卷号	11 期号:6
英文摘要	In this study, we developed a novel on-line solid phase extraction (SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites (methamphetamine, amphetamine, morphine, codeine, 6-monoacetylmorphine, benzoylecgonine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine, cocaine, ketamine, norketamine, and methcathinone) and cotinine (COT) in wastewater samples. The analysis was performed by loading 2 mL of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step (5% methanol) to eliminate interference with a total run time of 13 min. The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process. Typical analytical characteristics used for method validation were sensitivity, linearity, precision, repeatability, recovery, and matrix effects. The limit of detection (LOD) and limit of quantification (LOQ) of each target were set at 0.20 ng/L and 0.50 ng/L, respectively. The linearity was between 0.5 ng/L and 250 ng/L, except for that of COT. The intra- and inter-day precisions were <10.45% and 25.64%, respectively, and the relative recovery ranged from 83.74% to 162.26%. The method was used to analyze various wastewater samples from 33 cities in China, and the results were compared with the experimental results of identical samples analyzed using off-line SPE. The difference rate was between 19.91% and -20.44%, and the error range could be considered acceptable. These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples. (C) 2021 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
英文关键词	Illicit drugs and metabolites Wastewater analysis On-line solid phase extraction Ultra-high-performance liquid chromatography Mass spectrometry
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000738315700009
WOS关键词	MAJOR CHINESE CITIES ; LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; SEWAGE WATER ; ABUSE ; PHARMACEUTICALS ; SAMPLES ; EPIDEMIOLOGY ; VARIABILITY ; CONSUMPTION
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/375653
作者单位	[Wang, Jingyuan; Qi, Likai; Hou, Chenzhi; Chen, Mengyi; Su, Mengxiang; Di, Bin] China Pharmaceut Univ, Dept Pharm, Nanjing 210009, Peoples R China; [Wang, Jingyuan; Qi, Likai; Hou, Chenzhi; Zhang, Tingting; Chen, Mengyi; Su, Mengxiang; Xu, Hui; Hua, Zhendong; Wang, Youmei; Di, Bin] China Natl Narcot Control Commiss China Pharmaceu, Nanjing 210009, Peoples R China; [Zhang, Tingting; Hua, Zhendong; Wang, Youmei] Minist Publ Secur Peoples Republ China, Drug Control Informat & Technol Ctr, Beijing 100741, Peoples R China; [Zhang, Tingting; Hua, Zhendong; Wang, Youmei] Minist Publ Secur Peoples Republ China, Key Lab Drug Monitoring & Control, Beijing 100741, Peoples R China; [Meng, Haitao] Shimadzu China Co Ltd, Analyt Applicat Ctr, Analyt Instruments Div, Nanjing 210000, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jingyuan,Qi, Likai,Hou, Chenzhi,et al. Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS[J],2021,11(6).
APA	Wang, Jingyuan.,Qi, Likai.,Hou, Chenzhi.,Zhang, Tingting.,Chen, Mengyi.,...&Di, Bin.(2021).Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS.JOURNAL OF PHARMACEUTICAL ANALYSIS,11(6).
MLA	Wang, Jingyuan,et al."Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS".JOURNAL OF PHARMACEUTICAL ANALYSIS 11.6(2021).