干旱区生态环境知识资源中心(Arid): Transforming representations of movement from body- to world-centric space

Arid

DOI	10.1038/s41586-021-04191-x
	Transforming representations of movement from body- to world-centric space
	Lu, Jenny; Behbahani, Amir H.; Hamburg, Lydia; Westeinde, Elena A.; Dawson, Paul M.; Lyu, Cheng; Maimon, Gaby; Dickinson, Michael H.; Druckmann, Shaul; Wilson, Rachel, I
通讯作者	Wilson, RI (corresponding author), Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA. ; Wilson, RI (corresponding author), Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA.
来源期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2021-12
英文摘要	When an animal moves through the world, its brain receives a stream of information about the body'stranslational velocity from motor commands and sensory feedback signals. These incoming signals are referenced to the body, but ultimately, they must be transformed into world-centric coordinates for navigation(1,2). Here we show that this computation occurs in the fan-shaped body in the brain of Drosophila melanogaster. We identify two cell types, PFNd and PFNv(3-5), that conjunctively encode translational velocity and heading as a fly walks. In these cells, velocity signals are acquired from locomotor brain regions(6) and are multiplied with heading signals from the compass system. PFNd neurons prefer forward-ipsilateral movement, whereas PFNv neurons prefer backward-contralateral movement, and perturbing PFNd neurons disrupts idiothetic path integration in walking flies(7). Downstream, PFNd and PFNv neurons converge onto h Delta B neurons, with a connectivity pattern that pools together heading and translation direction combinations corresponding to the same movement in world-centric space. This network motif effectively performs a rotation of the brain's representation of body-centric translational velocity according to the current heading direction. Consistent with our predictions, we observe that h Delta B neurons form a representation of translational velocity in world-centric coordinates. By integrating this representation overtime, it should be possible for the brain to form a working memory of the path travelled through the environment(8-10).
类型	Article ; Early Access
语种	英语
开放获取类型	Green Submitted, Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000730529300010
WOS关键词	PATH-INTEGRATION ; DESERT ANTS ; EXPRESSION ; DISTANCE ; MOTION ; TOOLS ; MODEL
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374721
作者单位	[Lu, Jenny; Westeinde, Elena A.; Dawson, Paul M.; Wilson, Rachel, I] Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA; [Lu, Jenny; Westeinde, Elena A.; Dawson, Paul M.; Wilson, Rachel, I] Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA; [Behbahani, Amir H.; Dickinson, Michael H.] CALTECH, Div Biol & Biol Engn, Pasadena, CA USA; [Hamburg, Lydia; Druckmann, Shaul] Stanford Univ, Dept Neurobiol, Stanford, CA USA; [Lyu, Cheng; Maimon, Gaby] Rockefeller Univ, Lab Integrat Brain Funct, 1230 York Ave, New York, NY 10021 USA; [Lyu, Cheng; Maimon, Gaby] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA
推荐引用方式 GB/T 7714	Lu, Jenny,Behbahani, Amir H.,Hamburg, Lydia,et al. Transforming representations of movement from body- to world-centric space[J],2021.
APA	Lu, Jenny.,Behbahani, Amir H..,Hamburg, Lydia.,Westeinde, Elena A..,Dawson, Paul M..,...&Wilson, Rachel, I.(2021).Transforming representations of movement from body- to world-centric space.NATURE.
MLA	Lu, Jenny,et al."Transforming representations of movement from body- to world-centric space".NATURE (2021).