干旱区生态环境知识资源中心(Arid): Tumor-immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas

Arid

DOI	10.1002/path.5832
	Tumor-immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas
	Soeratram, Tanya T. D.; Creemers, Aafke; Meijer, Sybren L.; de Boer, Onno J.; Vos, Wim; Hooijer, Gerrit K. J.; van Berge Henegouwen, Mark, I; Hulshof, Maarten C. C. M.; Bergman, Jacques J. G. H. M.; Lei, Ming; Bijlsma, Maarten F.; Ylstra, Bauke; van Grieken, Nicole C. T.; van Laarhoven, Hanneke W. M.
通讯作者	van Laarhoven, HWM (corresponding author), Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Dept Med Oncol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
来源期刊	JOURNAL OF PATHOLOGY
ISSN	0022-3417
EISSN	1096-9896
出版年	2022
英文摘要	Immunotherapy is a new anti-cancer treatment option, showing promising results in clinical trials. To investigate potential immune biomarkers in esophageal adenocarcinoma (EAC), we explored immune landscape patterns in the tumor microenvironment before and after neoadjuvant chemoradiation (nCRT). Sections from matched pretreatment biopsies and post-nCRT resection specimens (n = 188) were stained for (1) programmed death-ligand 1 (PD-L1, CD274); (2) programmed cell death protein 1 (PD-1, CD279), forkhead box P3 (FOXP3), CD8, pan-cytokeratin multiplex; and (3) an MHC class I, II duplex. The densities of tumor-associated immune cells (TAICs) were calculated using digital image analyses and correlated to histopathological nCRT response [tumor regression grade (TRG)], survival, and post-nCRT immune patterns. PD-L1 positivity defined by a combined positive score of >1 was associated with a better response post-nCRT (TRG 1-3 versus 4, 5, p = 0.010). In addition, high combined mean densities of CD8(+), FOXP3(+), and PD-1(+) TAICs in the tumor epithelium and stroma of biopsies were associated with a better response (TRG 1-3 versus 4, 5, p = 0.025 and p = 0.044, respectively). Heterogeneous TAIC density patterns were observed post-nCRT, with significantly higher CD8(+) and PD-1(+) TAIC mean densities compared with biopsies (both p = 0.000). Three immune landscape patterns were defined post-nCRT: 'inflamed', 'invasive margin', and 'desert', of which 'inflamed' was the most frequent (57%). Compared with matched biopsies, resection specimens with 'inflamed' tumors showed a significantly higher increase in CD8(+) density compared with non-inflamed tumors post-nCRT (p = 0.000). In this cohort of EAC patients, higher TAIC densities in pretreatment biopsies were associated with response to nCRT. This warrants future research into the potential of the tumor-immune landscape for patient stratification and novel (immune) therapeutic strategies. (c) 2021 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
英文关键词	esophageal adenocarcinoma tumor-immune microenvironment PD-L1 tumor-infiltrating lymphocytes chemoradiotherapy treatment response digital image analysis immunohistochemistry biomarker
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000728573200001
WOS关键词	PREOPERATIVE CHEMORADIOTHERAPY ; NEOADJUVANT CHEMORADIOTHERAPY ; JUNCTIONAL CANCER ; SURVIVAL ; CHEMOTHERAPY ; SURGERY ; IMAGE ; CARCINOMA ; NIVOLUMAB
WOS类目	Oncology ; Pathology
WOS研究方向	Oncology ; Pathology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374703
作者单位	[Soeratram, Tanya T. D.; Vos, Wim; Ylstra, Bauke; van Grieken, Nicole C. T.] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Dept Pathol, Amsterdam, Netherlands; [Creemers, Aafke; Bijlsma, Maarten F.; van Laarhoven, Hanneke W. M.] Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Lab Expt Oncol & Radiobiol, Amsterdam, Netherlands; [Creemers, Aafke; van Laarhoven, Hanneke W. M.] Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Dept Med Oncol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands; [Meijer, Sybren L.; de Boer, Onno J.; Hooijer, Gerrit K. J.] Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Dept Pathol, Amsterdam, Netherlands; [van Berge Henegouwen, Mark, I] Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Dept Surg, Amsterdam, Netherlands; [Hulshof, Maarten C. C. M.] Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Dept Radiotherapy, Amsterdam, Netherlands; [Bergman, Jacques J. G. H. M.] Univ Amsterdam, Canc Ctr Amsterdam, Amsterdam UMC, Dept Gastroenterol, Amsterdam, Netherlan...
推荐引用方式 GB/T 7714	Soeratram, Tanya T. D.,Creemers, Aafke,Meijer, Sybren L.,et al. Tumor-immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas[J],2022.
APA	Soeratram, Tanya T. D..,Creemers, Aafke.,Meijer, Sybren L..,de Boer, Onno J..,Vos, Wim.,...&van Laarhoven, Hanneke W. M..(2022).Tumor-immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas.JOURNAL OF PATHOLOGY.
MLA	Soeratram, Tanya T. D.,et al."Tumor-immune landscape patterns before and after chemoradiation in resectable esophageal adenocarcinomas".JOURNAL OF PATHOLOGY (2022).