干旱区生态环境知识资源中心(Arid): Implementation of RNAi-based arthropod pest control: environmental risks, potential for resistance and regulatory considerations

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DOI	10.1007/s10340-021-01439-3
	Implementation of RNAi-based arthropod pest control: environmental risks, potential for resistance and regulatory considerations
	Christiaens, Olivier; Sweet, Jeremy; Dzhambazova, Teodora; Urru, Isabella; Smagghe, Guy; Kostov, Kaloyan; Arpaia, Salvatore
通讯作者	Christiaens, O (corresponding author), Univ Ghent, Dept Plants & Crops, Coupure Links 653, B-9000 Ghent, Belgium.
来源期刊	JOURNAL OF PEST SCIENCE
ISSN	1612-4758
EISSN	1612-4766
出版年	2022
英文摘要	Just over 20 years since the RNA interference (RNAi) mechanism was unraveled in the nematode Caenorhabditis elegans, the first RNAi-based pest control applications are close to commercialization. One of the most alluring aspects of this technology is its predicted minimal impact on the environment, due to high target selectivity and the short persistence of the active molecules in the environment. However, gaps of knowledge on the RNAi mechanism in many species and their implications for biosafety still exist. In this review, we present a comprehensive overview of the research conducted in this field. We discuss potential in planta and topical application methods in the field and their consequences regarding potential exposure in different non-target organisms (NTOs). While RNAi is assumed to be highly species selective, due to its sequence-guided mode of action, dsRNA design will determine how selective a product is. We also discuss molecular and cellular mechanisms affecting RNAi efficacy and how these could become a basis for the emergence of resistance against RNAi-based control products and highlight the need for resistance management. Finally, we briefly discuss recommendations for environmental risk assessment (ERA), such as the value of bioinformatics and the development of properly designed bioassays to predict effects in NTOs or to select NTOs for informing ERA.
英文关键词	RNA interference RNAi pesticide Crop protection Environmental risk assessment Biosafety Resistance
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000722499200002
WOS关键词	DOUBLE-STRANDED-RNA ; DIABROTICA-VIRGIFERA-VIRGIFERA ; WESTERN CORN-ROOTWORM ; DESERT LOCUST ; NUCLEASE ACTIVITY ; TARGETED ACTIVITY ; INTERFERENCE ; DSRNA ; SENSITIVITY ; EXPRESSION
WOS类目	Entomology
WOS研究方向	Entomology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374625
作者单位	[Christiaens, Olivier; Smagghe, Guy] Univ Ghent, Dept Plants & Crops, Coupure Links 653, B-9000 Ghent, Belgium; [Sweet, Jeremy] Sweet Environm Consultants, 6 Green St, Cambridge CB24 5JA, England; [Dzhambazova, Teodora; Kostov, Kaloyan] Agrobioinstitute ABI, Blvd Dragan Tsankov 8, Sofia 1164, Bulgaria; [Urru, Isabella; Arpaia, Salvatore] Italian Natl Agcy New Technol Energy & Sustainabl, ENEA, SS106,Km 419-5, I-75026 Rotondella, MT, Italy
推荐引用方式 GB/T 7714	Christiaens, Olivier,Sweet, Jeremy,Dzhambazova, Teodora,et al. Implementation of RNAi-based arthropod pest control: environmental risks, potential for resistance and regulatory considerations[J],2022.
APA	Christiaens, Olivier.,Sweet, Jeremy.,Dzhambazova, Teodora.,Urru, Isabella.,Smagghe, Guy.,...&Arpaia, Salvatore.(2022).Implementation of RNAi-based arthropod pest control: environmental risks, potential for resistance and regulatory considerations.JOURNAL OF PEST SCIENCE.
MLA	Christiaens, Olivier,et al."Implementation of RNAi-based arthropod pest control: environmental risks, potential for resistance and regulatory considerations".JOURNAL OF PEST SCIENCE (2022).