干旱区生态环境知识资源中心(Arid): Licania rigida leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects

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DOI	10.1080/15287394.2021.2002744
	Licania rigida leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects
	Batista, Debora; Duarte da Luz, Jefferson Romaryo; Silva Do Nascimento, Thayse Evellyn; de Senes-Lopes, Tiago Felipe; Galdino, Ony Araujo; Victor e Silva, Saulo; Ferreira, Macelia Pinheiro; dos Santos Azevedo, Marcelo Arrison; Brandao-Neto, Jose; Araujo-Silva, Gabriel; Lopez, Jorge A.; Almeida, Maria das Gracas
通讯作者	Almeida, MD (corresponding author), Univ Fed Rio Grande do Norte, Multidisciplinary Res Lab, Fac Pharm, R Gen Gustavo Cordeiro Farias S-N, BR-59012570 Natal, RN, Brazil.
来源期刊	JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
ISSN	1528-7394
EISSN	1087-2620
出版年	2022
英文摘要	Brazilian plant biodiversity is a rich alternative source of bioactive compounds since plant-derived extracts and/or their secondary metabolites exhibit potential properties to treat several diseases. In this context, Licania rigida Benth (Chrysobalanaceae Family), a large evergreen tree distributed in Brazilian semi-arid regions, deserves attention for its widespread use in popular medicine, although its biological properties are still poorly studied. The aim of this study was to examine (1) acute and sub-chronic oral toxicity at 2000 mg/kg dose; (2) in vitro cytotoxicity at 0.1; 1; 10; 100 or 1000 mu g/ml; (3) in vivo mutagenicity at 5, 10 or 20 mg/ml, and (4) potential antioxidant protective effect of L. rigida aqueous leaf extract of (AELr). No marked apparent toxic and genotoxic effects were observed using in vitro and in vivo assays after in vitro treatment of Chinese hamster ovary cell line (CHO-K1) with AELr or in vivo exposure of Wistar rats and Drosophila melanogaster to different extract concentrations. Concerning the antioxidant effect, the extract exhibited a protective effect by decreasing lipid peroxidation as determined by malondialdehyde levels. No significant changes were observed for glutathione (GSH) levels and activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Data demonstrate the beneficial potential of AELr to be employed for therapeutic purposes. However, further studies are required to validate the pharmacological application of this plant extract to develop as a phytotherapeutic formulation.
英文关键词	Licania rigida extract oiticica oxidative stress toxicity
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000720185500001
WOS关键词	SOMATIC MUTATION ; RECOMBINATION TEST ; GENOTOXICITY ; TOXICITY ; MEDICINES ; CHO-K1 ; ASSAYS ; DAMAGE ; DEATH ; CELLS
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374602
作者单位	[Batista, Debora; Duarte da Luz, Jefferson Romaryo; de Senes-Lopes, Tiago Felipe; Galdino, Ony Araujo; Almeida, Maria das Gracas] Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Dept Clin & Toxicol Anal, Postgrad Program Hlth Sci, Natal, RN, Brazil; [Batista, Debora; Duarte da Luz, Jefferson Romaryo; Silva Do Nascimento, Thayse Evellyn; de Senes-Lopes, Tiago Felipe; Galdino, Ony Araujo; Victor e Silva, Saulo; Ferreira, Macelia Pinheiro; dos Santos Azevedo, Marcelo Arrison; Almeida, Maria das Gracas] Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Dept Clin & Toxicol Anal, Multidisciplinary Res Lab, Natal, RN, Brazil; [Silva Do Nascimento, Thayse Evellyn; Victor e Silva, Saulo; Almeida, Maria das Gracas] Univ Fed Rio Grande do Norte, Dept Clin & Toxicol Anal, Multidisciplinary Res Lab, Hlth Sci Ctr,Postgrad Program Pharmaceut Sci, Natal, RN, Brazil; [Brandao-Neto, Jose] Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Dept Clin Med, Natal, RN, Brazil; [Araujo-Silva, Gabriel] Amapa State Univ Ueap, Fac Degree Chem, Orga...
推荐引用方式 GB/T 7714	Batista, Debora,Duarte da Luz, Jefferson Romaryo,Silva Do Nascimento, Thayse Evellyn,et al. Licania rigida leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects[J],2022.
APA	Batista, Debora.,Duarte da Luz, Jefferson Romaryo.,Silva Do Nascimento, Thayse Evellyn.,de Senes-Lopes, Tiago Felipe.,Galdino, Ony Araujo.,...&Almeida, Maria das Gracas.(2022).Licania rigida leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects.JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES.
MLA	Batista, Debora,et al."Licania rigida leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects".JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2022).