干旱区生态环境知识资源中心(Arid): Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy

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DOI	10.1016/j.coi.2021.10.004
	Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy
	Pocaterra, Arianna; Catucci, Marco; Mondino, Anna
通讯作者	Mondino, A (corresponding author), IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Lymphocyte Activat Unit, Via Olgettina 58, I-20132 Milan, Italy.
来源期刊	CURRENT OPINION IN IMMUNOLOGY
ISSN	0952-7915
EISSN	1879-0372
出版年	2022
卷号	74 页码:53-59
英文摘要	Adoptive T cell therapy (ACT) with tumor-reactive lymphocytes can overcome the immune desert of poorly immunogenic tumors and instruct tumor eradication. Several hurdles limit the efficacy of this strategy against solid tumor including, but not limited to, sub optimal T cell engraftment, tumor infiltration, poor tumor antigenicity/immunogenicity, and immunosuppressive or resistance mechanisms. Recent advances indicate that concomitant treatments can be set in place to offset such barriers. In this review, we highlight the beneficial effects of combining ACT with conventional chemo and/or radiotherapy. While originally classified as immunosuppressive, these methodologies can also promote the engraftment of ACT products, immunogenic cell death, and the reprogramming of more favorable microenvironments. Data indicates that systemic and local chemo/radiotherapy regimens promote intratumoral cytokine and chemokine upregulation, tumor antigen presentation and cross presentation, infiltration and in situ T cells reactivation. Here we review the most recent contributions supporting these notions and discuss further developments.
英文关键词	Adoptive T cell therapy TCR and CAR-T cells Solid tumors Immunogenic Cell Death Chemotherapy Radiotherapy Cytokines Combinatorial approaches
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000718166900001
WOS关键词	TNF-ALPHA ; ANTITUMOR EFFICACY ; BODY IRRADIATION ; PROSTATE-CANCER ; IMMUNOTHERAPY ; LYMPHODEPLETION ; EXPRESSION ; RADIATION ; INFILTRATION ; RADIOTHERAPY
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374543
作者单位	[Pocaterra, Arianna; Catucci, Marco; Mondino, Anna] IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Lymphocyte Activat Unit, Via Olgettina 58, I-20132 Milan, Italy
推荐引用方式 GB/T 7714	Pocaterra, Arianna,Catucci, Marco,Mondino, Anna. Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy[J],2022,74:53-59.
APA	Pocaterra, Arianna,Catucci, Marco,&Mondino, Anna.(2022).Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy.CURRENT OPINION IN IMMUNOLOGY,74,53-59.
MLA	Pocaterra, Arianna,et al."Adoptive T cell therapy of solid tumors: time to team up with immunogenic chemo/radiotherapy".CURRENT OPINION IN IMMUNOLOGY 74(2022):53-59.