干旱区生态环境知识资源中心(Arid): Formulation, characterization and biological evaluation of injectable nanocrystals from stem exudate gel of Caralluma retrospiciens (Ehrenb)-Part C

Arid

DOI	10.1016/j.arabjc.2021.1035791878-5352
	Formulation, characterization and biological evaluation of injectable nanocrystals from stem exudate gel of Caralluma retrospiciens (Ehrenb)-Part C
	Sultan, Muhammad H.; Moni, Sivakumar S.; Alqahtani, Saad S.; Makeen, Hafiz A.; Madkhali, Osama A.; Bakkari, Mohammed Ali; Menachery, Santhosh Joseph; Almoshari, Yosif; Salawi, Ahmad; Alshamrani, Meshal; Safhi, Awaji Y.; Mohan, Syam; Elmobark, Mohamed Eltaib
通讯作者	Moni, SS (corresponding author), Jazan Univ, Fac Pharm, Dept Pharmaceut, Jazan, Saudi Arabia. ; Makeen, HA (corresponding author), Jazan Univ, Fac Pharm, Clin Pharm Dept, Pharm Practice Res Unit, Jazan, Saudi Arabia.
来源期刊	ARABIAN JOURNAL OF CHEMISTRY
ISSN	1878-5352
EISSN	1878-5379
出版年	2022
卷号	15 期号:2
英文摘要	The purpose of this study was to develop injectable nanocrystals (NC) from stem exudate gel (EG) from Caralluma retrospiciens (Ehrenb) using the technique of nanoprecipitation. The NC had a zeta potential of -5.58 +/- 4.27 mV. Size distribution analysis showed that it ranged in size from 100 to 300 nm. The polydispersity index (PDI) was 0.467, while its percentage PDI was 68.4. Scanning electron microscopic analysis and transmission electron microscopy studies revealed the morphological features of NC as discrete crystals with rough surfaces. The mobility of NC was 5.5 mm.cm/Vs, while its conductivity was 0.16 mS/cm. Antibacterial studies showed broad activity against both Gram-positive and Gram-negative bacteria. The minimum inhibitory concentrations (MICs) of NC against Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), Streptococcus pyogenes (S. pyogenes), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumoniae (K. pneumoniae) were 6, 8, 8, 4, 8, and 6 % (w/v), respectively. The antibacterial effect was highest against K. pneumoniae (25.6 +/- 1.5 mm), followed by E. coli (25.5 +/- 1.8 mm), P. aeruginosa (24.1 +/- 1.2 mm), S. pyogenes (22.2 +/- 1.2 mm), S. aureus (21.83 +/- 1.2 mm) and B. subtilis (20.33 +/- 1.8 mm). In this study, the cytotoxicity properties of NC were determined against MCF-7 breast cancer cells ATCC. The NC failed to inhibit the proliferation of MCF-7 cells against the even at 300 mg/mL concentration. These results indicated that the NC is a promising antibacterial injectable dosage form. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
英文关键词	Nanocrystals Exudate gel Desert plant Caralluma retrospiciens Antibacterial properties
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000734869200011
WOS关键词	NANOPARTICLES
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374500
作者单位	[Sultan, Muhammad H.; Moni, Sivakumar S.; Madkhali, Osama A.; Bakkari, Mohammed Ali; Almoshari, Yosif; Salawi, Ahmad; Alshamrani, Meshal; Safhi, Awaji Y.; Elmobark, Mohamed Eltaib] Jazan Univ, Fac Pharm, Dept Pharmaceut, Jazan, Saudi Arabia; [Alqahtani, Saad S.; Makeen, Hafiz A.; Menachery, Santhosh Joseph] Jazan Univ, Fac Pharm, Clin Pharm Dept, Pharm Practice Res Unit, Jazan, Saudi Arabia; [Mohan, Syam] Jazan Univ, Subst Abuse & Toxicol Res Ctr, Jazan, Saudi Arabia
推荐引用方式 GB/T 7714	Sultan, Muhammad H.,Moni, Sivakumar S.,Alqahtani, Saad S.,et al. Formulation, characterization and biological evaluation of injectable nanocrystals from stem exudate gel of Caralluma retrospiciens (Ehrenb)-Part C[J],2022,15(2).
APA	Sultan, Muhammad H..,Moni, Sivakumar S..,Alqahtani, Saad S..,Makeen, Hafiz A..,Madkhali, Osama A..,...&Elmobark, Mohamed Eltaib.(2022).Formulation, characterization and biological evaluation of injectable nanocrystals from stem exudate gel of Caralluma retrospiciens (Ehrenb)-Part C.ARABIAN JOURNAL OF CHEMISTRY,15(2).
MLA	Sultan, Muhammad H.,et al."Formulation, characterization and biological evaluation of injectable nanocrystals from stem exudate gel of Caralluma retrospiciens (Ehrenb)-Part C".ARABIAN JOURNAL OF CHEMISTRY 15.2(2022).