干旱区生态环境知识资源中心(Arid): Determination of a comprehensive set of drugs of abuse, metabolites and human biomarkers in wastewater using passive sampling followed by UHPLC-MS/MS analysis

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DOI	10.1016/j.microc.2021.106960
	Determination of a comprehensive set of drugs of abuse, metabolites and human biomarkers in wastewater using passive sampling followed by UHPLC-MS/MS analysis
	Hahn, Roberta Zilles; Bastiani, Marcos Frank; Feltraco Lizot, Lilian de Lima; da Silva Moreira, Isabela Caroline; Meireles, Yasmin Fazenda; Schneider, Anelise; do Nascimento, Carlos Augusto; Linden, Rafael
通讯作者	Linden, R (corresponding author), Univ Feevale, Inst Ciencias Saude, Lab Anal Toxicol, Rua Rubem Berta 200, BR-93525080 Novo Hamburgo, RS, Brazil.
来源期刊	MICROCHEMICAL JOURNAL
ISSN	0026-265X
EISSN	1095-9149
出版年	2022
卷号	172
英文摘要	Passive sampling of wastewater using polar organic chemical integrative samplers (POCIS) is an interesting and cost-effective strategy for the quantification of biomarkers of drugs of abuse consumption in epidemiological studies. Particularly when combined with sensitive analytical method as ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS), POCIS sampling allows the long-term and sensitive determination of a wide range of analytes. In this study, a comprehensive analytical method integrating POCIS sampling, selective solid-phase extraction (SPE) of POCIS extracts, and analysis by UHPLC-MS/MS was developed and successfully validated for 12 biomarkers of substance use, with potential use in wastewater-based epidemiology. Chromatographic separation was achieved in 11 min. The assay has a wide liner range, with lower limits of quantification of 5 ng g-1 of POCIS sorbent. The selective SPE procedure, combining both cation and anion exchange cartridges, resulted in low matrix effects (-19.3 to 22.8% for compounds with a deuterated analog internal standard and 33.4 to 42.5% for anhydroecgonine methyl ester) and high extraction yields (93.4 to 106.4%). The lab-made POCIS sampler with Oasis (R) HLB sorbent was adequately calibrated for 9 compounds (4 drugs of abuse, 4 drug metabolites, and 1 human non-drug lifestyle markers). The method was applied in a wastewater treatment plant in Brazil, with continuous monitoring for 392 days in 2020-2021. The highest calculated wastewater concentration among drugs of abuse and metabolites was found for benzoylecgonine (431.5 +/- 190.6 ng L-1), followed by 11-nor-9-carboxy-Delta 9-THC (58.3 +/- 21.1 ng L-1). The assay described in this study can be used as an effective tool to monitor the presence of relevant drug consumption biomarkers in wastewater, a relevant epidemiologic strategy currently limited due to the sophisticated infrastructure needed for representative sampling.
英文关键词	Passive sampling Polar organic chemical integrative sampler Sampling rate Residual waters Drugs of abuse UHPLC-MS MS analysis
类型	Article
语种	英语
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000718381900003
WOS关键词	CHEMICAL INTEGRATIVE SAMPLER ; PERSONAL CARE PRODUCTS ; ILLICIT DRUGS ; MASS-SPECTROMETRY ; IN-SITU ; PHARMACEUTICALS ; CALIBRATION ; CONSUMPTION ; CONTAMINANTS ; SURFACE
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374437
作者单位	[Hahn, Roberta Zilles; Bastiani, Marcos Frank; Feltraco Lizot, Lilian de Lima; da Silva Moreira, Isabela Caroline; Meireles, Yasmin Fazenda; Schneider, Anelise; Linden, Rafael] Univ Feevale, Lab Analyt Toxicol, Rua Rubem Berta 200, BR-93525080 Novo Hamburgo, Brazil; [do Nascimento, Carlos Augusto] Fac Integradas Taquara, Dept Prod Engn, Av Oscar Martins Rangel 4500, BR-95612150 Taquara, Brazil; [Linden, Rafael] Natl Inst Forens Sci & Technol INCT Forense, Porto Alegre, RS, Brazil
推荐引用方式 GB/T 7714	Hahn, Roberta Zilles,Bastiani, Marcos Frank,Feltraco Lizot, Lilian de Lima,et al. Determination of a comprehensive set of drugs of abuse, metabolites and human biomarkers in wastewater using passive sampling followed by UHPLC-MS/MS analysis[J],2022,172.
APA	Hahn, Roberta Zilles.,Bastiani, Marcos Frank.,Feltraco Lizot, Lilian de Lima.,da Silva Moreira, Isabela Caroline.,Meireles, Yasmin Fazenda.,...&Linden, Rafael.(2022).Determination of a comprehensive set of drugs of abuse, metabolites and human biomarkers in wastewater using passive sampling followed by UHPLC-MS/MS analysis.MICROCHEMICAL JOURNAL,172.
MLA	Hahn, Roberta Zilles,et al."Determination of a comprehensive set of drugs of abuse, metabolites and human biomarkers in wastewater using passive sampling followed by UHPLC-MS/MS analysis".MICROCHEMICAL JOURNAL 172(2022).