干旱区生态环境知识资源中心(Arid): Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter

Arid

DOI	10.1016/j.envint.2021.106992
	Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter
	Aquilina, Noel J.; Havel, Christopher M.; Harrison, Roy M.; Ho, Kin-Fai; Benowitz, Neal L.; Jacob, Peyton, III
通讯作者	Aquilina, NJ (corresponding author), Univ Malta, Dept Chem, MSD-2080 Msida, Malta. ; Aquilina, NJ (corresponding author), Univ Calif San Francisco, Dept Med, Div Cardiol, Program Clin Pharmacol, San Francisco, CA 94143 USA.
来源期刊	ENVIRONMENT INTERNATIONAL
ISSN	0160-4120
EISSN	1873-6750
出版年	2022
卷号	158
英文摘要	The most important tobacco-specific nitrosamine found in cigarette smoke and formed in ageing smoke after cigarettes are extinguished is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). It is formed from nitrosation of nicotine, under particular conditions both in indoor and outdoor environments. NNK has been classified as a potent lung carcinogen which is expected to be found primarily in the particle-phase and to be stable in particulate matter. In this study tests have been carried out to show that a bisulfate-treated filter is more efficient than an untreated filter to collect both nicotine and NNK, and that the latter is stable in outdoor particulate matter. To characterize NNK in the outdoor environment, airborne samples were collected from 11 cities in USA, UK, Hong Kong and Malta with characteristics varying from low to high population densities and from urban to suburban to rural, and with desert characteristics and distinct climates. It has been shown that airborne particle + gas phase nicotine and particle-phase NNK behave in a linearly correlated manner. A seasonal analysis was carried out on a subset of data available from five sites in California, where the load of NNK in PM10 is driven by long range transport of the air masses passing over densely populated cities. In the winter season, the load of NNK in PM is higher than in summer in a statistically significant manner. The contamination of PM with NNK shows variability, but is observed at all sites. This paper highlights the potential risk of chronic exposure to NNK in particulate matter by the inhalation pathway.
英文关键词	Tobacco Smoke Tobacco-Specific Nitrosamines NNK Particulate Matter
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000726407600002
WOS关键词	PRESSURIZED LIQUID EXTRACTION ; N-NITROSAMINES ; NICOTINE ; MASS ; AIR ; OXIDATION ; DUST
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374401
作者单位	[Aquilina, Noel J.] Univ Malta, Dept Chem, MSD-2080 Msida, Malta; [Aquilina, Noel J.; Havel, Christopher M.; Benowitz, Neal L.; Jacob, Peyton, III] Univ Calif San Francisco, Dept Med, Div Cardiol, Program Clin Pharmacol, San Francisco, CA 94143 USA; [Harrison, Roy M.] Univ Birmingham, Sch Geog Earth & Environm Sci, Div Environm Hlth & Risk Management, Birmingham B15 2TT, W Midlands, England; [Ho, Kin-Fai] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China; [Harrison, Roy M.] King Abdulaziz Univ, Ctr Excellence Environm Studies, Dept Environm Sci, POB 80203, Jeddah 21589, Saudi Arabia
推荐引用方式 GB/T 7714	Aquilina, Noel J.,Havel, Christopher M.,Harrison, Roy M.,et al. Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter[J],2022,158.
APA	Aquilina, Noel J.,Havel, Christopher M.,Harrison, Roy M.,Ho, Kin-Fai,Benowitz, Neal L.,&Jacob, Peyton, III.(2022).Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter.ENVIRONMENT INTERNATIONAL,158.
MLA	Aquilina, Noel J.,et al."Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter".ENVIRONMENT INTERNATIONAL 158(2022).