干旱区生态环境知识资源中心(Arid): Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta

Arid

DOI	10.1016/j.biopha.2021.112478
	Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta
	Pereira, Joquebede Rodrigues; da Fonseca, Aldilane Goncalves; de Sena Fernandes, Luzia Leiros; Furtado, Allanny Alves; da Silva, Valeria Costa; da Veiga Junior, Valdir Florencio; Goulart Sant'Ana, Antonio Euzebio; Oliveira, Claudia Nunes; Bernardo Guerra, Gerlane Coelho; Fernandes-Pedrosa, Matheus De Freitas; Gavioli, Elaine Cristina; Oliveira-Costa, Jose Fernando; Pereira Soares, Milena Botelho; Neves de Lima, Adley Antonini; Silva, Daniel de Melo; Moura Lemos, Telma Maria Araujo
通讯作者	de Lima, AAN (corresponding author), Univ Fed Rio Grande do Norte, Dept Pharm, Lab Escola Farm Ind, BR-59012570 Natal, RN, Brazil.
来源期刊	BIOMEDICINE & PHARMACOTHERAPY
ISSN	0753-3322
EISSN	1950-6007
出版年	2022
卷号	145
英文摘要	Mansoa hirsuta is a medicinal plant native to the Brazilian semi-arid region. This approach aimed to investigate the in vitro and in vivo toxicity and anti-inflammatory and analgesic actions of the M. hirsuta fraction (MHF). In vitro cell viability was assessed in 3T3 cells. In vivo, the acute toxicity test, a single dose of the MHF was administered. For the subchronic toxicity test, three doses of were administered for 30 days. Locomotion and motor coordination were assessed using open field and rota-rod. The anti-inflammatory activity was evaluated in carrageenan-induced paw edema and zymosan-induced air-pouch models. Myeloperoxidase (MPO) and total proteins were also measured. The antinociceptive activity MHF was determined using acid acetic-induced abdominal writhing and formalin models. In the cytotoxicity assay, MHF showed no significative impairment of cell viability and in the acute toxicity study, did not cause mortality or signs of toxicity. Repeated exposure to MHF did not cause relevant toxicological changes. The evaluation in the open field test showed that the MHF did not alter the locomotor activity and there was no change in motor coordination and balance of animals. MHF significantly reduced edema, MPO production, the migration of leukocytes and protein leakage. In addition, MHF reduced abdominal writhing and significantly inhibited the first and second stage of the formalin test. The results of this study indicated that MHF has an anti-inflammatory and analgesic potential without causing acute or subchronic toxic effects and it can be a promising natural source to be explored.
英文关键词	Mansoa hirsuta Acute toxicity Subchronic toxicity Inflammation Analgesia
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000732827500005
WOS关键词	ACETIC-ACID ; ANIMAL-MODELS ; FORMALIN TEST ; IN-VITRO ; INFLAMMATION ; MYELOPEROXIDASE ; TOXICITY ; ZYMOSAN ; RATS ; ASSAY
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374381
作者单位	[Pereira, Joquebede Rodrigues; da Fonseca, Aldilane Goncalves; de Sena Fernandes, Luzia Leiros; Moura Lemos, Telma Maria Araujo] Univ Fed Rio Grande do Norte, Fac Pharm, Dept Clin & Toxicol Anal, BR-59012570 Natal, RN, Brazil; [Furtado, Allanny Alves; Fernandes-Pedrosa, Matheus De Freitas; Neves de Lima, Adley Antonini] Univ Fed Rio Grande do Norte, Dept Pharm, Lab Escola Farm Ind, BR-59012570 Natal, RN, Brazil; [da Silva, Valeria Costa; Bernardo Guerra, Gerlane Coelho; Gavioli, Elaine Cristina] Univ Fed Rio Grande do Norte, Ctr Biociencias, Dept Biophys & Pharmacol, BR-59078570 Natal, RN, Brazil; [da Veiga Junior, Valdir Florencio] Mil Inst Engn, Chem Engn Dept, BR-22290270 Rio De Janeiro, RJ, Brazil; [Goulart Sant'Ana, Antonio Euzebio] Univ Fed Alagoas, Inst Chem & Biotechnol, Campus AC Simoes, BR-57072970 Maceio, Alagoas, Brazil; [Oliveira, Claudia Nunes] Univ Fed Rio Grande do Norte, Dept Pathol, BR-59012570 Natal, RN, Brazil; [Oliveira-Costa, Jose Fernando; Pereira Soares, Milena Botelho] Pharmaceut ...
推荐引用方式 GB/T 7714	Pereira, Joquebede Rodrigues,da Fonseca, Aldilane Goncalves,de Sena Fernandes, Luzia Leiros,et al. Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta[J],2022,145.
APA	Pereira, Joquebede Rodrigues.,da Fonseca, Aldilane Goncalves.,de Sena Fernandes, Luzia Leiros.,Furtado, Allanny Alves.,da Silva, Valeria Costa.,...&Moura Lemos, Telma Maria Araujo.(2022).Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta.BIOMEDICINE & PHARMACOTHERAPY,145.
MLA	Pereira, Joquebede Rodrigues,et al."Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta".BIOMEDICINE & PHARMACOTHERAPY 145(2022).