干旱区生态环境知识资源中心(Arid): Active Antibiotics Production by Actinomycetes Indigenous To Saudi Arabia Soils

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DOI	10.22376/ijpbs/lpr.2021.11.6.L20-29
	Active Antibiotics Production by Actinomycetes Indigenous To Saudi Arabia Soils
	Alkhelaiwi, Fetoon M.; Ara, Ismet; Moubayed, Nadine
通讯作者	Alkhelaiwi, FM (corresponding author), King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi Arabia.
来源期刊	INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH
ISSN	2250-0480
出版年	2021
卷号	11 期号:6 页码:L20-L29
英文摘要	Streptomyces are the most popular among the Actinomycetes groups and found in soils worldwide. They form an important part of the soil ecology within the Actinomycetales order. Streptomyces are diverse as secondary antibiotic metabolites such as Novobiocin, Amphotericin, Vancomycin, Neomycin, Gentamicin, Chloramphenicol, Tetracycline, Erythromycin and Nystatin. Thus, the current study was aimed to isolate, identify and assess the active antibiotic metabolites produced by different actinomyces sp. found in Saudi Arabian soils. Six samples were collected from desert soils of the Al Thumamah area and analyzed using GS-MS. Scanning Electron Microscopy was used to identify the bacterial strains along with their antibiotic metabolites effectiveness of secondary metabolites (antibiotics) against different Gram-positive (Bacillus subtilis, Staphylococcus aureus), negative pathogens (Pseudomonas aeruginosa, Escherichia coli, Salmonella suis, and Shigella sonnei) as well as the fungal strain Candida albicans was investigated. Thirty active bacterial (F1-30) strains were isolated from the soil samples and the strains F3, F7, F22, F30 have white, gray, pink, yellow and red colours respectively. Only ten strains (F 13, F14, F15, F16, F17, F18, F19, F20, F2I, and F22) were found to have antimicrobial activity against at least one pathogen. The optimum growth environment was pH 4-10, temperature (30 degrees C), and NaCl (7% w/v) concentration. According to our findings, the extreme desert environment of Al Thumamah from Saudi Arabia is rich in its actinobacterial population with diverse colouring groups and various physiological and biochemical properties. This shows it's capability of generating secondary metabolite elements that could inhibit pathogenic microorganisms.
英文关键词	Natural Antibiotics Actinomycetes Saudi Arabia Soil Atinobacteria Strains Bacterial Isolates
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	ESCI
WOS记录号	WOS:000717914900004
WOS关键词	STREPTOMYCES ; TAXONOMY ; GENUS ; NOV
WOS类目	Chemistry, Medicinal
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374341
作者单位	[Alkhelaiwi, Fetoon M.; Ara, Ismet; Moubayed, Nadine] King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi Arabia
推荐引用方式 GB/T 7714	Alkhelaiwi, Fetoon M.,Ara, Ismet,Moubayed, Nadine. Active Antibiotics Production by Actinomycetes Indigenous To Saudi Arabia Soils[J],2021,11(6):L20-L29.
APA	Alkhelaiwi, Fetoon M.,Ara, Ismet,&Moubayed, Nadine.(2021).Active Antibiotics Production by Actinomycetes Indigenous To Saudi Arabia Soils.INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH,11(6),L20-L29.
MLA	Alkhelaiwi, Fetoon M.,et al."Active Antibiotics Production by Actinomycetes Indigenous To Saudi Arabia Soils".INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH 11.6(2021):L20-L29.