干旱区生态环境知识资源中心(Arid): Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin-LR Biosynthesis

Arid

DOI	10.21608/ejbo.2021.64662.1636
	Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin-LR Biosynthesis
	Hassoub, Mohamed A.; Abd El-Fatah, Sally, I; Marrez, Diaa A.; Saber, Abdullah A.
通讯作者	Saber, AA (corresponding author), Ain Shams Univ, Fac Sci, Bot Dept, Abbassia Sq, Cairo 11566, Egypt.
来源期刊	EGYPTIAN JOURNAL OF BOTANY
ISSN	0375-9237
EISSN	2357-0350
出版年	2021
卷号	61 期号:3 页码:879-889
英文摘要	THE HETEROCYTOUS cyanobacterium Westiellopsis prolifica has been recently documented in Egypt; however, our understanding of its diverse biotechnological and biomedical applications remains a limited and challenging topic. In this study, a W. prolifiica strain isolated from hyper-arid desert habitats was investigated to test its antimicrobial potential against six foodborne pathogenic bacteria (Bacillus cereus, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, and Klebsiella pneumoniae) and eight mycotoxigenic fungi (Aspergillus carbonarius, A. flavris, A. niger, A. ochraceus, A. parasiticus, A. westerdijikia, Fusarium proliferatum, and Penicillium verrucosum), as well as to evaluate its probable toxicity and biosynthesis of the most common inicrocystin variant (MC-LR) using high-performance liquid chromatography (FIPLC). The antimicrobial activity of various W. prolifica extracts was assessed using the disk-diffusion method, and the minimum inhibitory concentrations (MICs) were also determined. Our findings revealed that the extracts of drylanddwelling W. prolifica had significant antimicrobial activities against all tested bacterial and fungal strains, with average MIC values of 0.4-6.7 and 0.3-9.2mg.mL(-1), respectively. This antimicrobial potential can be ascribed to the combined synergistic effects of its biologically active and structurally diverse metabolites. Moreover, this species was a non-producer of MC-LR and was non-toxic based on the brine shrimp bioassay. Thus, the cyanoprokaryote W. prolifica can be considered a sustainable multifimctional candidate in the development of the pharmaceutical industry in Egypt.
英文关键词	Antibacterial and antifungal potential Cyanoprokaryotes Microcystin-LR Westiellopsis prolifica
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	ESCI
WOS记录号	WOS:000732424500017
WOS关键词	DESERT
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374223
作者单位	[Hassoub, Mohamed A.] Natl Res Ctr, Fertilizat Technol Dept, Algal Biotechnol Unit, Giza, Egypt; [Abd El-Fatah, Sally, I; Marrez, Diaa A.] Natl Res Ctr, Food Toxicol & Contaminants Dept, Giza, Egypt; [Saber, Abdullah A.] Ain Shams Univ, Fac Sci, Bot Dept, Abbassia Sq, Cairo 11566, Egypt
推荐引用方式 GB/T 7714	Hassoub, Mohamed A.,Abd El-Fatah, Sally, I,Marrez, Diaa A.,et al. Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin-LR Biosynthesis[J],2021,61(3):879-889.
APA	Hassoub, Mohamed A.,Abd El-Fatah, Sally, I,Marrez, Diaa A.,&Saber, Abdullah A..(2021).Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin-LR Biosynthesis.EGYPTIAN JOURNAL OF BOTANY,61(3),879-889.
MLA	Hassoub, Mohamed A.,et al."Antimicrobial Activity of the Heterocytous Cyanobacterium Westiellopsis prolifica and Assessment of Its Microcystin-LR Biosynthesis".EGYPTIAN JOURNAL OF BOTANY 61.3(2021):879-889.