干旱区生态环境知识资源中心(Arid): Predicting the individual probability of macular hole closure following intravitreal ocriplasmin injections for vitreomacular traction release using baseline characteristics

Arid

DOI	10.1038/s41598-021-03509-z
	Predicting the individual probability of macular hole closure following intravitreal ocriplasmin injections for vitreomacular traction release using baseline characteristics
	Bertelmann, Thomas; Berndzen, Lars; Raber, Thomas; Pfeiffer, Sebastian; Leha, Andreas; Paul, Christoph; Feltgen, Nicolas; Bemme, Sebastian
通讯作者	Bertelmann, T (corresponding author), Univ Med Ctr Goettingen, Dept Ophthalmol, Robert Koch Str 40, D-37075 Gottingen, Germany.
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2021
卷号	11 期号:1
英文摘要	The primary objective was to create and establish a new formula that predicts the individual probability of macular hole closure for eyes with full thickness macular holes (FTMH) accompanied by vitreomacular traction (VMT) which received enzymatic vitreolysis using intravitreally administered ocriplasmin. The secondary objective was to evaluate the forecast reliability of a previously published formula for VMT resolution in VMT-only eyes (Odds(IVO-Success) = e(Intercept )x OR(years )x ORln(mu m); Probability(IVO-Success) = Odds(IVO-Success)/(Odds(IVO-Success) + 1)) on VMT resolution using the current dataset of eyes with FTMH accompanied by VMT. Retrospective analysis of the OASIS, ORBIT, and INJECT-studies. Patients with FTMH and VMT with complete information (n = 213) were included. The effect of gender, age, FTMH diameter, lens status and the presence of epiretinal membranes (ERM) on FTMH closure was assessed using separate univariate logistic regression analyses. With regard to VMT release separate univariate regression analyses were carried out and results were compared with formerly published data of VMT resolution in eyes with VMT only. Overall, 126 eyes (63%) experienced VMT resolution within 28 days. Younger age (p < 0.0001) and VMT diameter (p = 0.041) had a significant impact on VMT release. Overall, 81 eyes (38%) treated with ocriplasmin showed FTMH closure within 28 days. Univariate analysis of the different predictors analyzed revealed that FTMH diameter < 250 mu m had a significant impact on treatment success (p = 0.0495). It was not possible to calculate and establish a new multivariate formula that can predict the individual FTMH closure probability for eyes with FTMHs and VMT. However, the results of VMT release prediction in eyes with FTMHs accompanied by VMT matched the prediction of VMT release in eyes with VMT only when using the previously published formula. All in all, predictors for calculating the individual probability of VMT resolution on the one hand and FTMH closure on the other hand are different suggesting diverse pathophysiological mechanisms.
类型	Article
语种	英语
开放获取类型	gold, Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000731098600045
WOS关键词	RESOLUTION ; ADHESION ; INTERFACE ; EFFICACY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374139
作者单位	[Bertelmann, Thomas; Berndzen, Lars; Feltgen, Nicolas; Bemme, Sebastian] Univ Med Ctr Goettingen, Dept Ophthalmol, Robert Koch Str 40, D-37075 Gottingen, Germany; [Raber, Thomas] Oxurion NV, Leuven, Belgium; [Pfeiffer, Sebastian] Univ Med Ctr Goettingen, UMG Study Ctr, Gottingen, Germany; [Leha, Andreas] Univ Med Ctr Goettingen, Dept Med Biometry & Stat Bioinformat, Gottingen, Germany; [Paul, Christoph] Philipps Univ Marburg, Dept Ophthalmol, Marburg, Germany
推荐引用方式 GB/T 7714	Bertelmann, Thomas,Berndzen, Lars,Raber, Thomas,et al. Predicting the individual probability of macular hole closure following intravitreal ocriplasmin injections for vitreomacular traction release using baseline characteristics[J],2021,11(1).
APA	Bertelmann, Thomas.,Berndzen, Lars.,Raber, Thomas.,Pfeiffer, Sebastian.,Leha, Andreas.,...&Bemme, Sebastian.(2021).Predicting the individual probability of macular hole closure following intravitreal ocriplasmin injections for vitreomacular traction release using baseline characteristics.SCIENTIFIC REPORTS,11(1).
MLA	Bertelmann, Thomas,et al."Predicting the individual probability of macular hole closure following intravitreal ocriplasmin injections for vitreomacular traction release using baseline characteristics".SCIENTIFIC REPORTS 11.1(2021).