干旱区生态环境知识资源中心(Arid): Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma

Arid

DOI	10.3389/fcell.2021.772436
	Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma
	Xu, Wenhao; Zhu, Wenkai; Tian, Xi; Liu, Wangrui; Wu, Yuanyuan; Anwaier, Aihetaimujiang; Su, Jiaqi; Wei, Shiyin; Qu, Yuanyuan; Zhang, Hailiang; Ye, Dingwei
通讯作者	Qu, YY ; Zhang, HL ; Ye, DW (corresponding author), Fudan Univ, Dept Urol, Shanghai Canc Ctr, Shanghai, Peoples R China. ; Qu, YY ; Zhang, HL ; Ye, DW (corresponding author), Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China. ; Wei, SY (corresponding author), Youjiang Med Univ Nationalities, Dept Neurosurg, Affiliated Hosp, Baise, Peoples R China.
来源期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
出版年	2021
卷号	9
英文摘要	The tumor microenvironment (TME) affects the biologic malignancy of clear cell renal cell carcinoma (ccRCC). The influence of the 5-methylcytosine (m(5)C) epigenetic modification on the TME is unknown. We comprehensively assessed m(5)C modification patterns of 860 ccRCC samples (training, testing, and real-world validation cohorts) based on 17 m(5)C regulators and systematically integrated the modification patterns with TME cell-infiltrating characterizations. Our results identified distinct m(5)C modification clusters with gradual levels of immune cell infiltration. The distinct m(5)C modification patterns differ in clinicopathological features, genetic heterogeneity, patient prognosis, and treatment responses of ccRCC. An elevated m(5)C score, characterized by malignant biologic processes of tumor cells and suppression of immunity response, implies an immune-desert TME phenotype and is associated with dismal prognosis of ccRCC. Activation of exhausted T cells and effective immune infiltration were observed in the low m(5)C score cluster, reflecting a noninflamed and immune-excluded TME phenotype with favorable survival and better responses to immunotherapy. Together, these findings provide insights into the regulation mechanisms of DNA m(5)C methylation modification patterns on the tumor immune microenvironment. Comprehensive assessment of tumor m(5)C modification patterns may enhance our understanding of TME cell-infiltrating characterizations and help establish precision immunotherapy strategies for individual ccRCC patients.
英文关键词	clear cell renal cell carcinoma 5-methylcytosine tumor microenvironment renal cell carcinoma (RCC) clear cell renal cell carcinoma (CCRCC) immune checkpoint therapies prognosis machine learning algorithm
类型	Article
语种	英语
开放获取类型	Green Accepted, gold
收录类别	SCI-E
WOS记录号	WOS:000732867700001
WOS关键词	CANCER ; REVEAL ; EXPRESSION ; THERAPIES
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374120
作者单位	[Xu, Wenhao; Zhu, Wenkai; Tian, Xi; Anwaier, Aihetaimujiang; Su, Jiaqi; Qu, Yuanyuan; Zhang, Hailiang; Ye, Dingwei] Fudan Univ, Dept Urol, Shanghai Canc Ctr, Shanghai, Peoples R China; [Xu, Wenhao; Zhu, Wenkai; Tian, Xi; Anwaier, Aihetaimujiang; Su, Jiaqi; Qu, Yuanyuan; Zhang, Hailiang; Ye, Dingwei] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China; [Liu, Wangrui; Wei, Shiyin] Youjiang Med Univ Nationalities, Dept Neurosurg, Affiliated Hosp, Baise, Peoples R China; [Wu, Yuanyuan] Naval Mil Med Univ, Naval Med Ctr PLA, Dept Gastroenterol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xu, Wenhao,Zhu, Wenkai,Tian, Xi,et al. Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma[J],2021,9.
APA	Xu, Wenhao.,Zhu, Wenkai.,Tian, Xi.,Liu, Wangrui.,Wu, Yuanyuan.,...&Ye, Dingwei.(2021).Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9.
MLA	Xu, Wenhao,et al."Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2021).