干旱区生态环境知识资源中心(Arid): Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds

Arid

DOI	10.1186/s12917-021-03077-4
	Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds
	Saadatabadi, Leila Mohamadipoor; Mohammadabadi, Mohammadreza; Ghanatsaman, Zeinab Amiri; Babenko, Olena; Stavetska, Ruslana; Kalashnik, Oleksandr; Kucher, Dmytro; Kochuk-Yashchenko, Oleksandr; Nanaei, Hojjat Asadollahpour
通讯作者	Mohammadabadi, M (corresponding author), Shahid Bahonar Univ Kerman, Dept Anim Sci, Kerman, Iran. ; Nanaei, HA (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China.
来源期刊	BMC VETERINARY RESEARCH
EISSN	1746-6148
出版年	2021
卷号	17 期号:1
英文摘要	Background Sheep were among the first animals to be domesticated. They are raised all over the world and produce a major scale of animal-based protein for human consumption and play an important role in agricultural economy. Iran is one of the important locations for sheep genetic resources in the world. Here, we compared the Illumina Ovine SNP50 BeadChip data of three Iranian local breeds (Moghani, Afshari and Gezel), as a population that does not undergone artificial breeding programs as yet, and five other sheep breeds namely East Friesian white, East Friesian brown, Lacaune, DorsetHorn and Texel to detect genetic mechanisms underlying economical traits and daptation to harsh environments in sheep. Results To identify genomic regions that have been targeted by positive selection, we used fixation index (Fst) and nucleotide diversity (Pi) statistics. Further analysis indicated candidate genes involved in different important traits such as; wool production included crimp of wool (PTPN3, NBEA and KRTAP20-2 genes), fiber diameter (PIK3R4 gene), hair follicle development (LHX2 gene), the growth and development of fiber (COL17A1 gene)), adaptation to hot arid environments (CORIN gene), adaptive in deficit water status (CPQ gene), heat stress (PLCB4, FAM107B, NBEA, PIK3C2B and USP43 genes) in sheep. Conclusions We detected several candidate genes related to wool production traits and adaptation to hot arid environments in sheep that can be applicable for inbreeding goals. Our findings not only include the results of previous researches, but also identify a number of novel candidate genes related to studied traits. However, more works will be essential to acknowledge phenotype- genotype relationships of the identified genes in our study.
英文关键词	Candidate genes Middle east ovis aries Positive selection
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000726073000003
WOS关键词	HEAT-STRESS ; CLOSTRIDIUM-PERFRINGENS ; BODY-WEIGHT ; IDENTIFICATION ; TEMPERATURE ; DIVERSITY ; PTPH1 ; CORIN
WOS类目	Veterinary Sciences
WOS研究方向	Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374111
作者单位	[Saadatabadi, Leila Mohamadipoor; Mohammadabadi, Mohammadreza] Shahid Bahonar Univ Kerman, Dept Anim Sci, Kerman, Iran; [Ghanatsaman, Zeinab Amiri] Agr Res Educ & Extens Org AREEO, Fars Agr & Nat Resources Res & Educ Ctr, Dept Anim Sci, Shiraz, Iran; [Babenko, Olena; Stavetska, Ruslana] Bila Tserkva Natl Agr Univ, Dept Anim Sci, Bila Tserkva, Kyivska Oblast, Ukraine; [Kalashnik, Oleksandr] Sumy Natl Agr Univ, Dept Anim Sci, Sumy, Ukraine; [Kucher, Dmytro; Kochuk-Yashchenko, Oleksandr] Polissia Natl Univ, Dept Breeding Anim Genet & Biotechnol, Zhytomyr, Ukraine; [Nanaei, Hojjat Asadollahpour] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Saadatabadi, Leila Mohamadipoor,Mohammadabadi, Mohammadreza,Ghanatsaman, Zeinab Amiri,et al. Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds[J],2021,17(1).
APA	Saadatabadi, Leila Mohamadipoor.,Mohammadabadi, Mohammadreza.,Ghanatsaman, Zeinab Amiri.,Babenko, Olena.,Stavetska, Ruslana.,...&Nanaei, Hojjat Asadollahpour.(2021).Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds.BMC VETERINARY RESEARCH,17(1).
MLA	Saadatabadi, Leila Mohamadipoor,et al."Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds".BMC VETERINARY RESEARCH 17.1(2021).