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DOI	10.1007/s13205-021-03049-3
	Innate and adaptive resistance to RNAi: a major challenge and hurdle to the development of double stranded RNA-based pesticides
	Choudhary, Chhavi; Meghwanshi, Keshav Kumar; Shukla, Nidhi; Shukla, Jayendra Nath
通讯作者	Shukla, JN (corresponding author), Cent Univ Rajasthan, Dept Biotechnol, NH-8, Kishangarh 305817, Rajasthan, India.
来源期刊	3 BIOTECH
ISSN	2190-572X
EISSN	2190-5738
出版年	2021
卷号	11 期号:12
英文摘要	RNA interference (RNAi) is a post-transcriptional gene silencing process where short interfering RNAs degrade targeted mRNA. Exploration of gene function through reverse genetics is the major achievement of RNAi discovery. Besides, RNAi can be used as a potential strategy for the control of insect pests. This has led to the idea of developing RNAi-based pesticides. Differential RNAi efficiency in the different insect orders is the biggest biological obstacle in developing RNAi-based pesticides. dsRNA stability, the sensitivity of core RNAi machinery, uptake of dsRNA and amplification and spreading of the RNAi signal are the key factors responsible for RNAi efficiency in insects. This review discusses the physiological and adaptive factors responsible for reduced RNAi in insects that pose a major challenge in developing dsRNA- based pesticides.
英文关键词	RNA interference Short interfering RNA Reverse genetics RNAi efficiency RNAi-based pesticides
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000719321400001
WOS关键词	COLORADO POTATO BEETLE ; WESTERN CORN-ROOTWORM ; DESERT LOCUST ; SYSTEMIC RNAI ; LEPTINOTARSA-DECEMLINEATA ; NUCLEASE ACTIVITY ; CURRENT PROGRESS ; DISTINCT ROLES ; SIRNA PATHWAY ; FALL ARMYWORM
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374098
作者单位	[Choudhary, Chhavi; Meghwanshi, Keshav Kumar; Shukla, Jayendra Nath] Cent Univ Rajasthan, Dept Biotechnol, NH-8, Kishangarh 305817, Rajasthan, India; [Shukla, Nidhi] Birla Inst Sci Res, Prithviraj Rd, Jaipur 302001, Rajasthan, India
推荐引用方式 GB/T 7714	Choudhary, Chhavi,Meghwanshi, Keshav Kumar,Shukla, Nidhi,et al. Innate and adaptive resistance to RNAi: a major challenge and hurdle to the development of double stranded RNA-based pesticides[J],2021,11(12).
APA	Choudhary, Chhavi,Meghwanshi, Keshav Kumar,Shukla, Nidhi,&Shukla, Jayendra Nath.(2021).Innate and adaptive resistance to RNAi: a major challenge and hurdle to the development of double stranded RNA-based pesticides.3 BIOTECH,11(12).
MLA	Choudhary, Chhavi,et al."Innate and adaptive resistance to RNAi: a major challenge and hurdle to the development of double stranded RNA-based pesticides".3 BIOTECH 11.12(2021).