干旱区生态环境知识资源中心(Arid): Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma

Arid

DOI	10.1158/1078-0432.CCR-21-1893
	Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma
	Li, Binghao; Li, Guoqi; Yan, Xiaobo; Zhu, Dan; Lin, Patrick P.; Wang, Zenan; Qu, Hao; He, Xuexin; Fu, Yanbiao; Zhu, Xiuliang; Lin, Peng; Zhang, Jiangnan; Li, Xiaoya; Dai, Hui; Chen, Huabiao; Poznansky, Mark C.; Lin, Nong; Ye, Zhaoming
通讯作者	Lin, N ; Ye, ZM (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthoped, 866 Yuhangtang Rd, Hangzhou 310009, Peoples R China. ; Ye, ZM (corresponding author), Zhejiang Univ, Orthoped Res Inst, Hangzhou, Peoples R China. ; Ye, ZM (corresponding author), Key Lab Motor Syst Dis Res & Precis Therapy Zheji, Hangzhou, Peoples R China.
来源期刊	CLINICAL CANCER RESEARCH
ISSN	1078-0432
EISSN	1557-3265
出版年	2021
卷号	27 期号:23 页码:6543-6558
英文摘要	Purpose: There is still no standard nonsurgical regimen for conventional chondrosarcoma (CHS). We aimed to identify whether any CHSs have a favored microenvironment for immunotherapy via multidimensional evaluation of the immunologic characteristics of this tumor. Experimental Design: We obtained 98 newly-diagnosed CHS fresh tumors from several institutions and performed comprehensive analysis of data from CyTOF, whole-exome sequencing, and flow cytometry in 22 cases. Clinical data from immunotherapy responders and nonresponders were compared to explore possible biomarkers of immunotherapy response. Mechanism studies were conducted to interpret the biomarker phenotype. Results: Based on the integrated data of single-cell CyTOF and flow cytometry, the CHS immune-microenvironment phenotypes were classified into three groups: subtype I, the granulocytic-myeloid-derived suppressor cell (G- MDSC) dominant cluster, with high number of HLA-DR-CD14-myeloid cells; subtype II, the immune exhausted cluster, with high exhausted T-cell and dendritic-cell infiltration; and subtype III, the immune desert cluster, with few immune cells. Immune cell-rich subtypes (subtype I and II) were characterized by IDH mutation, pathologic high grade, and peritumoral edema, while subtype I cases were exclusively featured by myxoid transformation. In clinical practice involving 12 individuals who received PD-1 antibody immuno-therapy, all of the 3 cases with controlled diseases were retrospectively classified as subtype II. In mechanism, IDH mutation significantly elevated chemokine levels and immune-cell infiltration in immune-inactivated tumors. Conclusions: This study is the first to provide immune characterization of CHS, representing a major step to precise immuno-therapy against this malignancy. Immunotherapy is promising for the immune exhausted subtype of patients with CHS.
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000726565500001
WOS关键词	GIANT-CELL TUMOR ; MURAMYL TRIPEPTIDE ; EXPRESSION ; CHEMOTHERAPY ; MUTATIONS ; CARCINOMA ; PD-L1
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374034
作者单位	[Li, Binghao; Yan, Xiaobo; Qu, Hao; He, Xuexin; Fu, Yanbiao; Lin, Peng; Zhang, Jiangnan; Li, Xiaoya; Lin, Nong; Ye, Zhaoming] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthoped, 866 Yuhangtang Rd, Hangzhou 310009, Peoples R China; [Li, Binghao; Li, Guoqi; Wang, Zenan; Lin, Peng; Ye, Zhaoming] Zhejiang Univ, Orthoped Res Inst, Hangzhou, Peoples R China; [Li, Binghao; Li, Guoqi; Yan, Xiaobo; Wang, Zenan; Lin, Nong; Ye, Zhaoming] Key Lab Motor Syst Dis Res & Precis Therapy Zheji, Hangzhou, Peoples R China; [Zhu, Dan] PLTTECH Inst, Div Mass Cytometry, Hangzhou, Peoples R China; [Lin, Patrick P.] Univ Texas MD Anderson Canc Ctr, Dept Orthopaed Oncol, Houston, TX 77030 USA; [He, Xuexin] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Oncol, Hangzhou, Peoples R China; [Fu, Yanbiao] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Pathol, Hangzhou, Peoples R China; [Zhu, Xiuliang] Zhejiang Univ, Dept Radiol, Affiliated Hosp 2, Sch Med, Hangzhou, Peoples R China; [Dai, Hui] Hangzhou Canc Hosp, Dept Radiothera...
推荐引用方式 GB/T 7714	Li, Binghao,Li, Guoqi,Yan, Xiaobo,et al. Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma[J],2021,27(23):6543-6558.
APA	Li, Binghao.,Li, Guoqi.,Yan, Xiaobo.,Zhu, Dan.,Lin, Patrick P..,...&Ye, Zhaoming.(2021).Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma.CLINICAL CANCER RESEARCH,27(23),6543-6558.
MLA	Li, Binghao,et al."Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma".CLINICAL CANCER RESEARCH 27.23(2021):6543-6558.