干旱区生态环境知识资源中心(Arid): Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Arid

DOI	10.1016/S2665-9913(21)00316-7
	Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study
	Sattui, Sebastian E.; Conway, Richard; Putman, Michael S.; Seet, Andrea M.; Gianfrancesco, Milena A.; Beins, Kaley; Hill, Catherine; Liew, David; Mackie, Sarah L.; Mehta, Puja; Neill, Lorna; Gomez, Gimena; Salinas, Maria Isabel Haye; Maldonado, Federico Nicolas; Mariz, Henrique Ataide; Studart, Samia Araujo de Sousa; Araujo, Nafice Costa; Knight, Ann; Rozza, Davide; Quartuccio, Luca; Samson, Maxime; Bally, Stephane; Maria, Alexandre T. J.; Chazerain, Pascal; Hasseli, Rebecca; Muller-Ladner, Ulf; Hoyer, Bimba F.; Voll, Reinhard; Torres, Rita Pinheiro; Luis, Mariana; Ribeirio, Sandra Lucia Euzebio; Al-Emadi, Samar; Sparks, Jeffrey A.; Hsu, Tiffany Y-T; D'Silva, Kristin M.; Patel, Naomi J.; Wise, Leanna; Gilbert, Emily; Almada, Maria Valenzuela; Duarte-Garcia, Ali; Ugarte-Gil, Manuel; Jacobsohn, Lindsay; Izadi, Zara; Strangfeld, Anja; Mateus, Elsa F.; Hyrich, Kimme L.; Gossec, Laure; Carmona, Loreto; Lawson-Tovey, Saskia; Kearsley-Fleet, Lianne; Schaefer, Martin; Sirotich, Emily; Hausmann, Jonathan S.; Sufka, Paul; Bhana, Suleman; Liew, Jean W.; Grainger, Rebecca; Machado, Pedro M.; Wallace, Zachary S.; Yazdany, Jinoos; Robinson, Philip C.
通讯作者	Sattui, SE (corresponding author), Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA. ; Conway, R (corresponding author), St James Hosp, Dept Rheumatol, Dublin D08 NHY1, Ireland.
来源期刊	LANCET RHEUMATOLOGY
ISSN	2665-9913
出版年	2021
卷号	3 期号:12 页码:E855-E864
英文摘要	Background Patients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica. Methods In this retrospective cohort study, adult patients (aged >= 18 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Behcet's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease. Findings Of 1202 eligible patients identified in the registry, 733 (61.0%) were women arid 469 (39.0%) were men, and their mean age was 63.8 years (SD 17.1). A total of 374 (31.1%) patients had polymyalgia rheumatica, 353 (29.4%) had ANCA-associated vasculitis, 183 (15.2%) had giant cell arteritis, 112 (9.3%) had Behcet's syndrome, and 180 (15.0%) had other vasculitis. Of 1020 (84. 9%) patients with outcome data, 512 (S0.2%) were not hospitalised, 114 (11.2%) were hospitalised and did not receive supplemental oxygen, 239 (23 - 4%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15.2%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1.44 [95% CI 1. 31-1- 571), were male compared with female (1.38 [1.05-1.801), had more comorbidities (per each additional comorbidity 1.39 [1- 23-1- 581), were taking 10 mg/day or more of prednisolone compared with none (2.14 [1.50-3.04J), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2.12 [1.49-3.021). Risk factors varied among different disease subtypes. Interpretation Among patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to info rm mitigation strategies for patients with these diseases. Copyright (C) 2021 Elsevier Ltd. All rights reserved.
类型	Article
语种	英语
开放获取类型	Green Submitted, Green Published, Bronze
收录类别	SCI-E
WOS记录号	WOS:000726733500011
WOS类目	Rheumatology
WOS研究方向	Rheumatology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/374002
作者单位	[Sattui, Sebastian E.] Hosp Special Surg, Dept Med, Div Rheumatol, 535 E 70th St, New York, NY 10021 USA; [Sattui, Sebastian E.] Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA; [Conway, Richard] St James Hosp, Dept Rheumatol, Dublin D08 NHY1, Ireland; [Putman, Michael S.] Med Coll Wisconsin, Milwaukee, WI 53226 USA; [Seet, Andrea M.; Gianfrancesco, Milena A.; Jacobsohn, Lindsay; Izadi, Zara; Yazdany, Jinoos] Univ Calif San Francisco, Dept Med, Div Rheumatol, San Francisco, CA 94143 USA; [Beins, Kaley] Vasculitis Fdn, Kansas City, MO USA; [Hill, Catherine] Queen Elizabeth Hosp, Rheumatol Unit, Woodville, SA, Australia; [Hill, Catherine] Univ Adelaide, Discipline Med, Adelaide, SA, Australia; [Liew, David] Austin Hlth, Dept Rheumatol, Melbourne, Vic, Australia; [Liew, David] Univ Melbourne, Dept Med, Melbourne, Vic, Australia; [Mackie, Sarah L.] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England; [Mackie, Sarah L.] Leeds Teaching Hosp NHS Trust, Leeds ...
推荐引用方式 GB/T 7714	Sattui, Sebastian E.,Conway, Richard,Putman, Michael S.,et al. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study[J],2021,3(12):E855-E864.
APA	Sattui, Sebastian E..,Conway, Richard.,Putman, Michael S..,Seet, Andrea M..,Gianfrancesco, Milena A..,...&Robinson, Philip C..(2021).Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study.LANCET RHEUMATOLOGY,3(12),E855-E864.
MLA	Sattui, Sebastian E.,et al."Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study".LANCET RHEUMATOLOGY 3.12(2021):E855-E864.