干旱区生态环境知识资源中心(Arid): Performance of bone tracer for diagnosis and differentiation of transthyretin cardiac amyloidosis: a systematic review and meta-analysis

Arid

DOI	10.5152/dir.2021.20662
	Performance of bone tracer for diagnosis and differentiation of transthyretin cardiac amyloidosis: a systematic review and meta-analysis
	Zhao, Hongliang; Hu, Haijuan; Cui, Wei
通讯作者	Cui, W (corresponding author), Hebei Med Univ, Hosp 2, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China. ; Cui, W (corresponding author), Inst Cardiocerebrovasc Dis Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
来源期刊	DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
EISSN	1305-3612
出版年	2021
卷号	27 期号:6 页码:802-810
英文摘要	PURPOSE Bone tracers have been validated for many years in detecting transthyretin cardiac amyloidosis (TTR-CA). However, several new studies suggest conflicting results. Our study aimed to systemically evaluate the accuracy of bone radiotracers for diagnosis and differentiation of TTR-CA via a systematic review and meta-analysis. METHODS We retrieved articles assessing the performance of bone tracer in diagnosing and differentiating TTR-CA from PubMed, the Cochrane Library, ScienceDirect, and DOAJ databases, dating up to 10 July 2020. The meta-analysis was conducted through Stata 16 software, and the risk of bias for the included studies was assessed by the QUADAS-2 tool. Moreover, we made a comprehensive review. RESULTS Four teen articles were included in the systematic review, and 9 in the meta-analysis. The pooled sensitivity was 0.97 (95% confidence interval [95% CI] 0.85-0.99) with heterogeneity (I-2=73.5, 95% CI 55.6-91.2), arid the specificity was 0.92 (95% CI 0.82-0.96) with heterogeneity (I-2=42.0, 95% CI 0.0-86.9). The pooled positive arid negative likelihood ratios were 11.49 (95% CI 5.07-26.0) arid 0.03 (95% CI 0.01-0.18), respectively. The diagnostic odds ratio was 341 (95% CI 53-2194), and the area under the receiver operating characteristic curve was 0.96 (95% CI 0.94-0.97). CONCLUSION The findings evidence that the bone radiotracer is a valuable noninvasive approach that provides high accuracy for diagnosing TTR-CA and plays a modest role in differentiating TTR-CA from irnrnunoglobulin amyloid light-chain cardiac amyloidosis. Tc-99m-HMDP may be more ac curate than Tc-99m-PYP, Tc-99m-DPD, arid F-18-NaF in the TTR-CA detecting process, and F-18-NaF is a promising bone tracer to diagnose arid differentiate TTR-CA.
类型	Review
语种	英语
开放获取类型	Green Published
收录类别	SCI-E
WOS记录号	WOS:000721235900017
WOS关键词	TC-99M-DPD SCINTIGRAPHY ; ETIOLOGIC DIAGNOSIS ; TC-99M-PYROPHOSPHATE ; UTILITY ; BIOPSY ; ATTR
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/373810
作者单位	[Zhao, Hongliang; Hu, Haijuan; Cui, Wei] Hebei Med Univ, Hosp 2, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China; [Zhao, Hongliang; Hu, Haijuan; Cui, Wei] Inst Cardiocerebrovasc Dis Hebei Prov, Shijiazhuang, Hebei, Peoples R China; [Zhao, Hongliang] Hebei Med Univ, Hosp 1, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Hongliang,Hu, Haijuan,Cui, Wei. Performance of bone tracer for diagnosis and differentiation of transthyretin cardiac amyloidosis: a systematic review and meta-analysis[J],2021,27(6):802-810.
APA	Zhao, Hongliang,Hu, Haijuan,&Cui, Wei.(2021).Performance of bone tracer for diagnosis and differentiation of transthyretin cardiac amyloidosis: a systematic review and meta-analysis.DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY,27(6),802-810.
MLA	Zhao, Hongliang,et al."Performance of bone tracer for diagnosis and differentiation of transthyretin cardiac amyloidosis: a systematic review and meta-analysis".DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY 27.6(2021):802-810.