干旱区生态环境知识资源中心(Arid): 3-Hydroxy-5,6-epoxy-beta-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation

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DOI	10.3390/app112210929
	3-Hydroxy-5,6-epoxy-beta-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation
	Sanjeewa, K. K. Asanka; Kim, Hyun-Soo; Lee, Hyo-Geun; Jayawardena, Thilina U.; Nagahawatta, D. P.; Yang, Hye-Won; Udayanga, Dhanushka; Kim, Jae-Il; Jeon, You-Jin
通讯作者	Jeon, YJ (corresponding author), Jeju Natl Univ, Sch Marine Biomed Sci, Dept Marine Life Sci, Jeju 63243, South Korea. ; Kim, JI (corresponding author), Pukyong Natl Univ, Dept Food Sci & Nutr, Yongso Ro 45, Busan 608737, South Korea. ; Jeon, YJ (corresponding author), Jeju Natl Univ, Inst Marine Sci, Jeju 63333, South Korea.
来源期刊	APPLIED SCIENCES-BASEL
EISSN	2076-3417
出版年	2021
卷号	11 期号:22
英文摘要	Featured ApplicationFunctional foods and nutraceuticals.Air pollution is a process that mixes pollutants into the atmosphere, which is potentially harmful to humans and causes negative impacts on the surrounding environment (biotic and abiotic). The negative health effects associated with air pollution have been reported from both indoor and outdoor environments. Specifically, dust storms originating in Chinese and Mongolian desert areas introduce significant amounts of particulate matter (PM) to the Korean atmosphere. Previously, several studies reported that urban PM (UPM) is a potential agent that causes inflammation in the lungs by altering multiple signal transduction pathways; therefore, screening and identification of anti-inflammatory compounds against UPM-induced inflammation is an urgent requirement. In the present study, we attempted to study the anti-inflammatory properties of 3-Hydroxy-5,6-epoxy-beta-ionone (HEBI), a pure compound isolated from invasive brown seaweed, Sargassum horneri (brown edible seaweed), against UPM-stimulated lung macrophages (MH-S). Anti-inflammatory parameters of HEBI were evaluated using Western blots, ELISA, RT-qPCR, and MTT assays. According to the results, HEBI at concentrations between 31.3 and 125 mu g/mL reduced UPM-induced NO, PGE2, and pro-inflammatory cytokine production via blocking the downstream signal transduction of NF-kappa B and MAPKs. Specifically, HEBI down-regulated the mRNA expression levels of Toll-like receptors 2 and 4, which are well-known NF-kappa B and MAPKs stimulators. Taken together, HEBI is a potential candidate to develop functional foods and active ingredients in cosmeceuticals because of its profound effects against UPM-induced inflammation in MH-S macrophages.
英文关键词	lung macrophages inflammation oxidative stress Sargassum horneri particulate matter
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000724555800001
WOS关键词	NF-KAPPA-B ; SIGNAL-TRANSDUCTION PATHWAYS ; SOUTH-KOREA ; STRESS ; RESPONSES ; DUST ; MACROPHAGES ; EXPRESSION ; COMPONENTS ; PM2.5
WOS类目	Chemistry, Multidisciplinary ; Engineering, Multidisciplinary ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Chemistry ; Engineering ; Materials Science ; Physics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/373768
作者单位	[Sanjeewa, K. K. Asanka; Udayanga, Dhanushka] Univ Sri Jayewardenepura, Fac Technol, Dept Biosyst Technol, Pitipana 10206, Homagama, Sri Lanka; [Sanjeewa, K. K. Asanka; Kim, Hyun-Soo; Lee, Hyo-Geun; Jayawardena, Thilina U.; Nagahawatta, D. P.; Yang, Hye-Won; Jeon, You-Jin] Jeju Natl Univ, Sch Marine Biomed Sci, Dept Marine Life Sci, Jeju 63243, South Korea; [Kim, Hyun-Soo] Natl Marine Biodivers Inst Korea, Dept Appl Res, Seocheon 325902, South Korea; [Kim, Jae-Il] Pukyong Natl Univ, Dept Food Sci & Nutr, Yongso Ro 45, Busan 608737, South Korea; [Jeon, You-Jin] Jeju Natl Univ, Inst Marine Sci, Jeju 63333, South Korea
推荐引用方式 GB/T 7714	Sanjeewa, K. K. Asanka,Kim, Hyun-Soo,Lee, Hyo-Geun,et al. 3-Hydroxy-5,6-epoxy-beta-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation[J],2021,11(22).
APA	Sanjeewa, K. K. Asanka.,Kim, Hyun-Soo.,Lee, Hyo-Geun.,Jayawardena, Thilina U..,Nagahawatta, D. P..,...&Jeon, You-Jin.(2021).3-Hydroxy-5,6-epoxy-beta-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation.APPLIED SCIENCES-BASEL,11(22).
MLA	Sanjeewa, K. K. Asanka,et al."3-Hydroxy-5,6-epoxy-beta-ionone Isolated from Invasive Harmful Brown Seaweed Sargassum Horneri Protects MH-S Mouse Lung Cells from Urban Particulate Matter-Induced Inflammation".APPLIED SCIENCES-BASEL 11.22(2021).