干旱区生态环境知识资源中心(Arid): Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro

Arid

DOI	10.3390/app112210822
	Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro
	Kang, Yun-Mi; Lee, Jeonghoon; Kim, Wonnam; Jin, Jong-Sik; Lee, Jong-Hyun; An, Hyo-Jin
通讯作者	An, HJ (corresponding author), Sangji Univ, Coll Korean Med, Dept Pharmacol, 83 Sangjidae Gil, Wonju 26339, Gangwon Do, South Korea.
来源期刊	APPLIED SCIENCES-BASEL
EISSN	2076-3417
出版年	2021
卷号	11 期号:22
英文摘要	Licorice is the common name of Glycyrrhiza species, which is an important plant for edible and medicinal purposes; however, Glycyrrhiza resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For this reason, a novel Glycyrrhiza variety named Wongam, a hybrid of G. glabra and G. uralensis, was developed by the Korea Rural Development Administration. To elucidate the antiallergic inflammatory effects of Wongam, we investigated its effects using a compound-48/80-induced anaphylaxis in vivo model and PMA/A23187-stimulated HMC-1 cells and immunoglobulin E (IgE)/DNP-stimulated RBL-2H3 cells in in vitro models. Wongam treatment reduced mortality and serum IgE levels and downregulated proinflammatory cytokines and chemokines in a compound-48/80-induced anaphylaxis mouse model. Wongam decreased histamine release and the expression of proinflammatory cytokines in HMC-1 and RBL-2H3 cells. Wongam treatment downregulated the expression of chemokines, T helper 2 cytokines, and cell surface antigens in PMA/A23187-stimulated HMC-1 cells. We confirmed that these effects were associated with the inhibition of the MAPK and NF-kappa B signaling pathways by Wongam. The present study suggests that Wongam ameliorates mast-cell-mediated allergic inflammatory responses by reducing mast cell activation and may serve as an effective agent for the prevention and treatment of allergic inflammatory responses.
英文关键词	allergy inflammation novel Glycyrrhiza varieties Wongam mast cell activation anaphylaxis
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000724852000001
WOS关键词	MAST-CELL DEGRANULATION ; IGE ; EXTRACT ; EXPRESSION ; URALENSIS ; GLABRA ; RADIX ; CD63
WOS类目	Chemistry, Multidisciplinary ; Engineering, Multidisciplinary ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Chemistry ; Engineering ; Materials Science ; Physics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/373744
作者单位	[Kang, Yun-Mi; An, Hyo-Jin] Sangji Univ, Coll Korean Med, Dept Pharmacol, 83 Sangjidae Gil, Wonju 26339, Gangwon Do, South Korea; [Lee, Jeonghoon] Rural Dev Adm, Herbal Crop Res Div, Natl Inst Hort & Herbal Sci, 92 Bisan Ro, Eumseong 27709, Chungbuk, South Korea; [Kim, Wonnam] Cnh Ctr Canc Res, 462 Bongeunsa Ro, Seoul 06154, South Korea; [Jin, Jong-Sik] Jeonbuk Natl Univ, Dept Oriental Med Resources, 79 Gobong Ro, Iksan 54596, Jeollabuk Do, South Korea; [Lee, Jong-Hyun] Dongduk Womens Univ, Coll Pharm, Dept Pharm, 60 Hwarang Ro 13 Gil, Seoul 02748, South Korea
推荐引用方式 GB/T 7714	Kang, Yun-Mi,Lee, Jeonghoon,Kim, Wonnam,et al. Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro[J],2021,11(22).
APA	Kang, Yun-Mi,Lee, Jeonghoon,Kim, Wonnam,Jin, Jong-Sik,Lee, Jong-Hyun,&An, Hyo-Jin.(2021).Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro.APPLIED SCIENCES-BASEL,11(22).
MLA	Kang, Yun-Mi,et al."Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro".APPLIED SCIENCES-BASEL 11.22(2021).