干旱区生态环境知识资源中心(Arid): Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer

Arid

DOI	10.3389/fimmu.2021.746647
	Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer
	Liu, Jinhui; Chen, Can; Wang, Yichun; Qian, Cheng; Wei, Junting; Xing, Yan; Bai, Jianling
通讯作者	Xing, Y (corresponding author), Nanjing Med Univ, Dept Gynecol, Affiliated Hosp 1, Nanjing, Peoples R China. ; Bai, JL (corresponding author), Nanjing Med Univ, Sch Publ Heath, Dept Biostat, Nanjing, Peoples R China.
来源期刊	FRONTIERS IN IMMUNOLOGY
ISSN	1664-3224
出版年	2021
卷号	12
英文摘要	Background recently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis. However, it remains unknown whether m1A modification has an effect in the prognosis of ovarian cancer (OC) and its immune infiltration. Methods Based on 10 m1A modulators, we comprehensively assessed m1A modification patterns in 474 OC patients and linked them to TME immune infiltration characteristics. m1Ascore computed with principal component analysis algorithm was applied to quantify m1A modification pattern in OC patients. m1A regulators protein and mRNA expression were respectively obtained by HPA website and RT-PCR in clinical OC and normal samples. Results We finally identified three different m1A modification patterns. The immune infiltration features of these m1A modification patterns correspond to three tumor immune phenotypes, including immune-desert, immune-inflamed and immune-excluded phenotypes. The results demonstrate individual tumor m1A modification patterns can predict patient survival, stage and grade. The m1Ascore was calculated to quantify individual OC patient's m1A modification pattern. A high m1Ascore is usually accompanied by a better survival advantage and a lower mutational load. Research on m1Ascore in the treatment of OC patients showed that patients with high m1Ascore showed marked therapeutic benefits and clinical outcomes in terms of chemotherapy and immunotherapy. Lastly, we obtained four small molecule drugs that may potentially ameliorate prognosis. Conclusion This research demonstrates that m1A methylation modification makes an essential function in the prognosis of OC and in shaping the immune microenvironment. Comprehensive evaluation of m1A modifications improves our knowledge of immune infiltration profile and provides a more efficient individualized immunotherapy strategy for OC patients.
英文关键词	ovarian cancer m1A modification tumor microenvironment prognosis immune checkpoint blockade
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000717842300001
WOS关键词	GENE-EXPRESSION ; ALKYLATION DAMAGE ; MESSENGER-RNA ; DEMETHYLATION ; LANDSCAPE ; BLOCKADE ; ANTIBODY ; SAFETY
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/373679
作者单位	[Liu, Jinhui; Qian, Cheng; Xing, Yan] Nanjing Med Univ, Dept Gynecol, Affiliated Hosp 1, Nanjing, Peoples R China; [Chen, Can] Nanjing Med Univ, Affiliated Hosp 1, Dept Lab Med, Nanjing, Peoples R China; [Wang, Yichun] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing, Peoples R China; [Wei, Junting] Nanjing Med Univ, Clin Sch 2, Nanjing, Peoples R China; [Bai, Jianling] Nanjing Med Univ, Sch Publ Heath, Dept Biostat, Nanjing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jinhui,Chen, Can,Wang, Yichun,et al. Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer[J],2021,12.
APA	Liu, Jinhui.,Chen, Can.,Wang, Yichun.,Qian, Cheng.,Wei, Junting.,...&Bai, Jianling.(2021).Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer.FRONTIERS IN IMMUNOLOGY,12.
MLA	Liu, Jinhui,et al."Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer".FRONTIERS IN IMMUNOLOGY 12(2021).