干旱区生态环境知识资源中心(Arid): Larrea tridentata and its Biological Activities

Arid

DOI	10.2174/1568026621666210727170908
	Larrea tridentata and its Biological Activities
	Reyes-Melo, Karen Y.; Galvan-Rodrigo, Adrian A.; Martinez-Olivo, Isai E.; Nunez-Mojica, Guillermo; Avalos-Alanis, Francisco G.; Garcia, Abraham; del Rayo Camacho-Corona, Maria
通讯作者	Camacho-Corona, MD (corresponding author), Univ Autonoma Nuevo Leon, Fac Ciencias Quim, San Nicolas De Los Garza 66455, Nuevo Leon, Mexico.
来源期刊	CURRENT TOPICS IN MEDICINAL CHEMISTRY
ISSN	1568-0266
EISSN	1873-5294
出版年	2021
卷号	21 期号:26 页码:2352-2364
英文摘要	Background: Larrea tridentata is a dominant shrub in the deserts of North America and is recognized for its various traditional uses. More than 50 traditional uses have been recorded. Re-garding its chemical composition, the products of the mevalonate, shikimate, and malonate path-ways are predominant. L. tridentata has nordihydroguaiaretic acid (NDGA), one of its most studied secondary metabolites that exhibited remarkable different biological activities: sequestration of re-active oxygen species, inhibition of lipoxygenases (LOX) and activation of the endogenous antioxi-dant response mediated by nuclear factor erythroid 2-related factor 2 (NRF2). Objective and Methods: This review seeks to draw attention to metabolites other than NDGA and which also contribute to the various biological activities of L. tridentata. Therefore, the present re-view includes those reports focused on the pharmacological properties of the organic extracts of L. tridentata and its natural products with promising values. Results and Conclusion: Among the most promising and widely reported metabolites from L. tri-dentata, are: 3'-demethoxy-6-O-demethylisoguaiacin, 3'-O-methyldihydroguaiaretic acid, meso-di-hydroguaiaretic acid, and tetra-O-methylnordihydroguaiaretic acid. These have been reported to ex-hibit antibacterial, antiprotozoal, anthelmintic, antifungal, antiviral, anticancer, and antioxidant ac-tivities.
英文关键词	Larrea tridentata Lignans Flavonoids Antibacterial Antiviral Anticancer Antioxidant
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000718007400001
WOS关键词	NORDIHYDROGUAIARETIC ACID ; POTENTIAL MECHANISM ; CREOSOTE BUSH ; PLANT LIGNAN ; EXTRACTS ; MEXICAN ; TUBERCULOSIS ; INHIBITION ; INGESTION ; HEPATITIS
WOS类目	Chemistry, Medicinal
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/373592
作者单位	[Reyes-Melo, Karen Y.; Galvan-Rodrigo, Adrian A.; Martinez-Olivo, Isai E.; Nunez-Mojica, Guillermo; Avalos-Alanis, Francisco G.; Garcia, Abraham; del Rayo Camacho-Corona, Maria] Univ Autonoma Nuevo Leon, Fac Ciencias Quim, San Nicolas De Los Garza 66455, Nuevo Leon, Mexico
推荐引用方式 GB/T 7714	Reyes-Melo, Karen Y.,Galvan-Rodrigo, Adrian A.,Martinez-Olivo, Isai E.,et al. Larrea tridentata and its Biological Activities[J],2021,21(26):2352-2364.
APA	Reyes-Melo, Karen Y..,Galvan-Rodrigo, Adrian A..,Martinez-Olivo, Isai E..,Nunez-Mojica, Guillermo.,Avalos-Alanis, Francisco G..,...&del Rayo Camacho-Corona, Maria.(2021).Larrea tridentata and its Biological Activities.CURRENT TOPICS IN MEDICINAL CHEMISTRY,21(26),2352-2364.
MLA	Reyes-Melo, Karen Y.,et al."Larrea tridentata and its Biological Activities".CURRENT TOPICS IN MEDICINAL CHEMISTRY 21.26(2021):2352-2364.