干旱区生态环境知识资源中心(Arid): GC-MS/MS-Based Phytochemical Screening of Therapeutic Potential of Calligonum polygonoides L. Flower Bud against Chronic Diseases

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DOI	10.4103/pm.pm_390_20
	GC-MS/MS-Based Phytochemical Screening of Therapeutic Potential of Calligonum polygonoides L. Flower Bud against Chronic Diseases
	Berwal, Mukesh Kumar; Haldhar, Shravan M.; Ram, Chet; Gora, Jagan Singh; Singh, Dhurendra; Samadia, D. K.
通讯作者	Berwal, MK (corresponding author), ICAR Cent Inst Arid Hort, Div Crop Improvement, Bikaner 334006, Rajasthan, India.
来源期刊	PHARMACOGNOSY MAGAZINE
ISSN	0973-1296
EISSN	0976-4062
出版年	2021
卷号	17 期号:5 页码:S68-S76
英文摘要	Background: Calligonum polygonoides is an endemic plant species, belongs to Polygonaceae family, native to the Thar Desert of India. It is highly tolerant to multiple stresses with dominant biomass and phytochemical producer under extreme niche. It has significant ethnopharmacological applications, but not yet scientifically validated. Materials and Methods: The methanolic extract of C. polygonoides flower bud was subjected to gas chromatography mass spectroscopy (GC-MS) analysis and antioxidant potential assay was done on different radical scavenging scales. The phytochemicals were identified based on retention time and matching their mass spectra to spectra in NIST 14 library. Results: The results revealed the presence of fatty acids, phenolics, terpenoides, flavanoids, alkaloids, tannins, steroids, ketones, esters, and amino acid derivatives, which comprises 93 compounds. Most of the detected compounds have been proved to possess important bio-activities such as anti-microbial, anti-inflammatory, anticancer, anti-diabetic, hepatoprotective, cardiovascular, antioxidant, and antimutagenic. Interestingly, some compounds such as furan-2,5-dimethyl, 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP), dehydromevalonic lactone, deoxyspergualin, 2-methoxy-4-vinylphenol, benzeneethanol-4-hydroxy-, quinic acid, lauric acid, linolenic acid, and squalene were detected which have proved pharmaceuticals applications against major diseases such as cancer, diabetics, cardiovascular, and some other chronic diseases. Furthermore, the methanolic extract also attributed very high level of antioxidant potential on cupric reducing antioxidant capacity, ferric reducing antioxidant power, 2,2-diphenyl-1-picrylhydrazyl, and phosphomolybdenum assay scales. Conclusion: The identified phytochemicals with ample pharmaceutical application explore the worthiness of this endemic plant species. Along with pharmaceutical, it has an immense scope in nutraceutical and functional food industry. These medicinal importance advised for its conservation and artificial regeneration, to sustain the agro-ecological balance of Thar Desert of India.
英文关键词	Bioactive compounds Calligonum polygonoides GC-MS/MS pharmaceutical applications phog phytochemical screening
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000725298400010
WOS关键词	ANTIOXIDANT CAPACITY ; ANIMAL-MODELS ; OLIVE OIL ; IN-VIVO ; SQUALENE ; TYROSOL ; 2,3-DIHYDRO-3,5-DIHYDROXY-6-METHYL-4H-PYRAN-4-ONE ; ENCEPHALOMYELITIS ; PROTECTS ; ACID
WOS类目	Chemistry, Medicinal
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/373576
作者单位	[Berwal, Mukesh Kumar; Haldhar, Shravan M.; Ram, Chet; Gora, Jagan Singh; Singh, Dhurendra; Samadia, D. K.] ICAR Cent Inst Arid Hort, Div Crop Improvement, Bikaner 334006, Rajasthan, India
推荐引用方式 GB/T 7714	Berwal, Mukesh Kumar,Haldhar, Shravan M.,Ram, Chet,et al. GC-MS/MS-Based Phytochemical Screening of Therapeutic Potential of Calligonum polygonoides L. Flower Bud against Chronic Diseases[J],2021,17(5):S68-S76.
APA	Berwal, Mukesh Kumar,Haldhar, Shravan M.,Ram, Chet,Gora, Jagan Singh,Singh, Dhurendra,&Samadia, D. K..(2021).GC-MS/MS-Based Phytochemical Screening of Therapeutic Potential of Calligonum polygonoides L. Flower Bud against Chronic Diseases.PHARMACOGNOSY MAGAZINE,17(5),S68-S76.
MLA	Berwal, Mukesh Kumar,et al."GC-MS/MS-Based Phytochemical Screening of Therapeutic Potential of Calligonum polygonoides L. Flower Bud against Chronic Diseases".PHARMACOGNOSY MAGAZINE 17.5(2021):S68-S76.