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	In Vitro Anti-Proliferative Potentials of Phaeangium lefebvrei Desert Truffle towards MCF-7, HepG2 and L929 Cell Lines
	Elsayed, E. A.; Alsahli, F. D.; Amr, A. E.; El Enshasy, H. A.; Wadaan, M. A.
通讯作者	Elsayed, EA (corresponding author), King Saud Univ, Coll Sci, Zool Dept, Bioprod Res Chair, Riyadh 11451, Saudi Arabia. ; Elsayed, EA (corresponding author), Natl Res Ctr, Nat & Microbial Prod Dept, Cairo 12311, Egypt.
来源期刊	JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH
ISSN	0022-4456
EISSN	0975-1084
出版年	2019
卷号	78 期号:12 页码:858-862
英文摘要	Phaeangium lefebvrei belongs to desert truffles found naturally in deserts in the Arab Peninsula, and mainly consumed by birds. Therefore, they still present a natural un investigated source for the presence of bioactive molecules. In the present investigation, we evaluated the anti-proliferative activities of different solvent extracts of P. lefebvrei against MCF-7, HepG2 and L929 cancer cells. Results showed that evaluated extracts have promising anticancer effects against different tested cell lines. Moreover, Ethyl acetate extract resulted in maximal growth inhibition against L929 cells (95.7 +/- 0.02%), while both ethyl acetate and hexane extracts inhibited MCF-7 cell growth by about 92.5 +/- 0.03 and 91.7 +/- 0.04%, respectively. Furthermore, the obtained IC50 values for these extracts against MCF-7 cells recorded 103.8 +/- 0.09 and 553.6 +/- 0.1 mu g/mL, respectively. Accordingly, desert truffles represent a significant potential in the development of promising anticancer pharmaceutical drugs.
英文关键词	Truffles Phaeangium lefebvrei Saudi Arabia Anticancer Cells
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000517355500009
WOS关键词	EXTRACTS
WOS类目	Engineering, Multidisciplinary
WOS研究方向	Engineering
来源机构	King Saud University
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/369621
作者单位	[Elsayed, E. A.; Wadaan, M. A.] King Saud Univ, Coll Sci, Zool Dept, Bioprod Res Chair, Riyadh 11451, Saudi Arabia; [Elsayed, E. A.] Natl Res Ctr, Nat & Microbial Prod Dept, Cairo 12311, Egypt; [Alsahli, F. D.] King Saud Univ, Coll Sci, Zool Dept, Riyadh 11451, Saudi Arabia; [Alsahli, F. D.] KACST, Natl Ctr Genome Technol, Life Sci & Environm Res Inst, Riyadh, Saudi Arabia; [Amr, A. E.] King Saud Univ, Coll Pharm, Drug Explorat & Dev Chair, Pharmaceut Chem Dept, Riyadh 11451, Saudi Arabia; [Amr, A. E.] Natl Res Ctr, Appl Organ Chem Dept, Cairo, Egypt; [El Enshasy, H. A.] Univ Teknol Malaysia, Inst Bioprod Dev, Johor Baharu 81310, Malaysia; [El Enshasy, H. A.] City Sci Res & Technol Applicat, Alexandria 21934, Egypt
推荐引用方式 GB/T 7714	Elsayed, E. A.,Alsahli, F. D.,Amr, A. E.,et al. In Vitro Anti-Proliferative Potentials of Phaeangium lefebvrei Desert Truffle towards MCF-7, HepG2 and L929 Cell Lines[J]. King Saud University,2019,78(12):858-862.
APA	Elsayed, E. A.,Alsahli, F. D.,Amr, A. E.,El Enshasy, H. A.,&Wadaan, M. A..(2019).In Vitro Anti-Proliferative Potentials of Phaeangium lefebvrei Desert Truffle towards MCF-7, HepG2 and L929 Cell Lines.JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH,78(12),858-862.
MLA	Elsayed, E. A.,et al."In Vitro Anti-Proliferative Potentials of Phaeangium lefebvrei Desert Truffle towards MCF-7, HepG2 and L929 Cell Lines".JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH 78.12(2019):858-862.