干旱区生态环境知识资源中心(Arid): The in vivo evaluation of antinociceptive and antipyretic activities of Marrubium deserti DDe Noe infusion extract

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	The in vivo evaluation of antinociceptive and antipyretic activities of Marrubium deserti DDe Noe infusion extract
	Somia, Saad; Saida, Ouafi
通讯作者	Somia, S (corresponding author), USTHB, Res Lab Arid Zones LRZA, Fac Biol Sci, BP 132, Algiers 16111, Algeria.
来源期刊	INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE
ISSN	0972-5938
EISSN	0975-1068
出版年	2019
卷号	18 期号:3 页码:468-476
英文摘要	The aim of this study was to evaluate the in vivo antinociceptive and antipyretic activities of Marrubium deserti De Noe infusion extract. Antinociceptive effect was evaluated by acetic acid induced writhing response, formalin-induced paw licking and the hot plat method in mice, while antipyretic activity was tested by brewer's yeast induced pyrexia in rats. In each test, we examined the doses of 250, 500 and 1000 mg/kg body weight (bw) of the extract. The infusion extract produced dose-dependent antinociceptive effect against chemically and thermally induced nociceptive pain stimuli in mice. In acetic acid induced writhing test, the inhibition percentage of writhing response was 49.12% at 1000 mg/kg bw (p<0.001). This extract also significantly (p<0.001) inhibited the licking response of the formalin test at 1000 mg/kg bw in both the early phase (64.39%) and the late phase (70.75%). In the hot plate method, the infusion extract significantly (p<0.001) increased the reaction time to heat sensation to 58.21% at 1000 mg/kg bw Moreover, the extract possessed an excellent (p<0.001) antipyretic effect and even better than the reference drug. These findings indicate that M. deserti De Noe infusion extract possesses antinociceptive and antipyretic activities which could be due to the presence of bioactive compounds in this plant.
英文关键词	M. deserti Infusion Phytochemical screening Acute toxicity Antinociceptive Antipyretic
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000500707300006
WOS关键词	ANTIOXIDANT ACTIVITY ; AQUEOUS EXTRACT ; ESSENTIAL OIL ; AERIAL PARTS ; FLAVONOIDS
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/369546
作者单位	[Somia, Saad; Saida, Ouafi] USTHB, Res Lab Arid Zones LRZA, Fac Biol Sci, BP 132, Algiers 16111, Algeria
推荐引用方式 GB/T 7714	Somia, Saad,Saida, Ouafi. The in vivo evaluation of antinociceptive and antipyretic activities of Marrubium deserti DDe Noe infusion extract[J],2019,18(3):468-476.
APA	Somia, Saad,&Saida, Ouafi.(2019).The in vivo evaluation of antinociceptive and antipyretic activities of Marrubium deserti DDe Noe infusion extract.INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE,18(3),468-476.
MLA	Somia, Saad,et al."The in vivo evaluation of antinociceptive and antipyretic activities of Marrubium deserti DDe Noe infusion extract".INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE 18.3(2019):468-476.