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DOI	10.1016/j.heliyon.2020.e05445
	Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle
	Lima, Crystianne Calado; de Holanda-Angelin-Alves, Camille Maria; Pereira-Goncalves, Atila; Kennedy-Feitosa, Emanuel; Evangelista-Costa, Eder; Carneiro Bezerra, Maria Amelia; Coelho-de-Souza, Andrelina Noronha; Leal-Cardoso, Jose Henrique
通讯作者	Leal-Cardoso, JH (corresponding author), Univ Estadual Ceara, Super Inst Biomed Sci, Lab Electrophysiol, Fortaleza, Ceara, Brazil.
来源期刊	HELIYON
EISSN	2405-8440
出版年	2020
卷号	6 期号:11
英文摘要	Croton zehntneri is a plant well adapted to the semi-arid climate of northeastern region of Brazil. The essential oil of C. zehntneri (EOCz) has been described to have several pharmacologic properties, including effect on airflow resistance of in vivo respiratory system. For this reason, we investigated the hypothesis that EOCz and its major constituents, anethole and estragole, have antispasmodic activity on tracheal muscle. In tracheal rings of Wistar rats, maintained in Krebs-Henseleit's solution, EOCz, anethole and estragole inhibited contractions induced by 60mM [K+], ACh (10 mu M), Ba2+ and Phorbol dibutirate (1 mu M). For EOCz, anethole and estragole, the IC50 for inhibition of KCl-induced contractions were 145.8 +/- 14.8, 89.9 +/- 7.4 and 181.0 +/- 23.3 mu g/mL, respectively, and for ACh-induced contraction, they were 606.1 +/- 122.0, 160.5 +/- 33.0 and 358.6 +/- 49.2 mu g/mL. Pharmacodynamic efficacy was maximal in all cases. These data in Ba2+-induced contraction and the differential IC50 suggested that blockade of Voltage Dependent Calcium Channels (VDCC) is a component of the mechanism of action of the three agents. Evaluation of the direct effect of anethole, on VDCC, showed inhibition of the Ca2+ current through this type of channel. These results show that EOCz and the constituents have antispasmodic activity and the mechanism includes blockade of VDCC channels.
英文关键词	Croton zehntneri Essential oil Anethole Estragole Trachealis smooth muscle Antispasmodic effect Pharmaceutical science Dose-response relationship Natural product Organ system Respiratory system
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000649388700054
WOS关键词	ZEHNTNERI ; LECHLERI ; CHANNEL ; EXCITABILITY ; PHARMACOLOGY ; INHIBITION ; ACTIVATION ; CHEMISTRY ; IMPROVES ; KINASE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/369161
作者单位	[Lima, Crystianne Calado] Univ Estadual Ceara, Super Inst Biomed Sci, Lab Pulm Physiol, Fortaleza, Ceara, Brazil; [de Holanda-Angelin-Alves, Camille Maria; Pereira-Goncalves, Atila; Evangelista-Costa, Eder; Coelho-de-Souza, Andrelina Noronha; Leal-Cardoso, Jose Henrique] Univ Estadual Ceara, Super Inst Biomed Sci, Lab Electrophysiol, Fortaleza, Ceara, Brazil; [Kennedy-Feitosa, Emanuel] Fed Rural Univ Semiarid, Dept Hlth Sci, Mossorro, RN, Brazil; [Carneiro Bezerra, Maria Amelia] State Univ Vale Acarau, Ctr Hlth Sci, Sobral, Ceara, Brazil
推荐引用方式 GB/T 7714	Lima, Crystianne Calado,de Holanda-Angelin-Alves, Camille Maria,Pereira-Goncalves, Atila,et al. Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle[J],2020,6(11).
APA	Lima, Crystianne Calado.,de Holanda-Angelin-Alves, Camille Maria.,Pereira-Goncalves, Atila.,Kennedy-Feitosa, Emanuel.,Evangelista-Costa, Eder.,...&Leal-Cardoso, Jose Henrique.(2020).Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle.HELIYON,6(11).
MLA	Lima, Crystianne Calado,et al."Antispasmodic effects of the essential oil of Croton zehnteneri, anethole, and estragole, on tracheal smooth muscle".HELIYON 6.11(2020).